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无多囊卵巢综合征患者的高催乳素血症与多毛症

Hyperprolactinemia and Hirsutism in Patients Without Polycystic Ovary Syndrome.

作者信息

Tirgar-Tabari Soudabeh, Sharbatdaran Majid, Manafi-Afkham Sara, Montazeri Mohammad

机构信息

Department of Dermatology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

Department of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

出版信息

Int J Trichology. 2016 Jul-Sep;8(3):130-4. doi: 10.4103/0974-7753.188998.

DOI:10.4103/0974-7753.188998
PMID:27625565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5007919/
Abstract

BACKGROUND

Hirsutism is one of the most important diseases that lead women to refer to dermatology clinic. Hyperprolactinemia is one of the causes of hirsutism. The aim of this study was to determine prolactin (PRL) levels in hirsute women.

MATERIALS AND METHODS

In this cross-sectional study, hirsute patients were evaluated. For all of the patients, 2 or 3 days after mense starting, hormone level tests were performed, and 200 patients that had not polycystic ovary syndrome enrolled to the study. A questionnaire of history and physical examination were performed. Data have been analyzed with SPSS version 21.

RESULTS

Hyperprolactinemia were seen in 25 patients (12.5%). There was no significant relation between marital statuses, galactorrhoea, positive family history, and infertility with hyperprolactinemia. But significant relation was seen between irregular mense and hyperprolactinemia.

CONCLUSION

Although hyperprolactinemia is the rare cause of hirsutism, the prevalence of hyperprolactinemia was high in our study. Thus, PRL level in hirsute patients should be evaluate.

摘要

背景

多毛症是导致女性前往皮肤科就诊的最重要疾病之一。高泌乳素血症是多毛症的病因之一。本研究的目的是测定多毛症女性的泌乳素(PRL)水平。

材料与方法

在这项横断面研究中,对多毛症患者进行了评估。对所有患者在月经开始后2或3天进行激素水平检测,200例无多囊卵巢综合征的患者纳入研究。进行了病史问卷调查和体格检查。数据采用SPSS 21版进行分析。

结果

25例患者(12.5%)出现高泌乳素血症。婚姻状况、溢乳、家族史阳性和不孕与高泌乳素血症之间无显著相关性。但月经不规律与高泌乳素血症之间存在显著相关性。

结论

虽然高泌乳素血症是多毛症的罕见病因,但在我们的研究中高泌乳素血症的患病率较高。因此,应评估多毛症患者的PRL水平。

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Reply to: Hyperprolactinemia and Hirsutism in Patients without Polycystic Ovary Syndrome.回复:非多囊卵巢综合征患者的高催乳素血症与多毛症
Int J Trichology. 2017 Jan-Mar;9(1):42. doi: 10.4103/ijt.ijt_88_16.

本文引用的文献

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The impact of polycystic ovary syndrome on the health-related quality of life: A systematic review and meta-analysis.多囊卵巢综合征对健康相关生活质量的影响:一项系统综述和荟萃分析。
Iran J Reprod Med. 2015 Feb;13(2):61-70.
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Obesity with irregular menstrual cycle in young girls.年轻女孩中伴有月经周期不规律的肥胖症。
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Metabolic syndrome and inflammatory biomarkers in adults: a population-based survey in Western region of iran.成人中的代谢综合征与炎症生物标志物:伊朗西部地区的一项基于人群的调查
Int Cardiovasc Res J. 2014 Dec;8(4):156-60. Epub 2014 Dec 1.
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Polycystic ovary syndrome: a review for dermatologists: Part I. Diagnosis and manifestations.多囊卵巢综合征:皮肤科医生的综述:第一部分。诊断与表现。
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Prolactin is associated with metabolic risk and cortisol in 1007 women with polycystic ovary syndrome.在1007名多囊卵巢综合征女性中,催乳素与代谢风险和皮质醇有关。
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Thyroid autoimmunity in patients with hyperprolactinemia: an observational study.高催乳素血症患者的甲状腺自身免疫:一项观察性研究。
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Semin Reprod Med. 2014 May;32(3):194-201. doi: 10.1055/s-0034-1371091. Epub 2014 Apr 8.
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Treatment of hyperprolactinemia: a systematic review and meta-analysis.高泌乳素血症的治疗:系统评价和荟萃分析。
Syst Rev. 2012 Jul 24;1:33. doi: 10.1186/2046-4053-1-33.