2007-2013 年，以色列南部实验室诊断的人类皮肤利什曼病病例急剧增加。

Dramatic increase in laboratory-diagnosed human cutaneous leishmaniasis cases in southern Israel, 2007-2013.

机构信息

From the Pediatric Infectious Disease Unit.

出版信息

Infect Dis (Lond). 2015 Mar;47(3):161-7. doi: 10.3109/00365548.2014.977342. Epub 2015 Jan 22.

DOI:10.3109/00365548.2014.977342

PMID:25622937

Abstract

BACKGROUND

Cutaneous leishmaniasis (CL) is an endemic zoonosis in southern Israel. In recent years, substantial urbanization has been taking place in this region. The introduction of populations into endemic foci was previously reported to facilitate human CL outbreaks. Our aim was to describe a continuous CL outbreak in southern Israel, through laboratory reports of CL diagnosis.

METHODS

The Soroka University Medical Center parasitology laboratory is the major laboratory confirming CL cases in our region. Data regarding patients referred to the hospital for CL diagnosis were collected retrospectively. Cases were defined by microscopic findings of skin lesion biopsies.

RESULTS

The annual number of cases sent for CL laboratory confirmation increased from a mean of 77 ± 9 in the years 2007-2010 to 178, 327, and 528 in the years 2011, 2012, and 2013, respectively. The respective increase in annual confirmed/positive cases of CL was from 36 ± 12 to 117, 171, and 282, leading to respective increase in CL rate (per 100 000) from 5.8 ± 1.9 to 18.4, 26.3, and 42.7. The outbreak was mainly (> 60%) observed in the north-west area of the region.

CONCLUSIONS

In conclusion, a sevenfold increase in laboratory-confirmed CL was observed in southern Israel in 2007-2013, probably reflecting a bigger outbreak, possibly related to urban expansion bordering with CL foci.

摘要

背景

皮肤利什曼病（CL）是以色列南部的地方性人畜共患病。近年来，该地区发生了大规模的城市化。先前有报道称，人群进入地方性流行地区有助于人类 CL 暴发。我们的目的是通过 CL 诊断的实验室报告来描述以色列南部的连续 CL 暴发。

方法

索罗卡大学医学中心寄生虫学实验室是本地区主要的 CL 病例确诊实验室。回顾性收集了关于因 CL 诊断而转至医院的患者的数据。通过皮肤病变活检的显微镜检查结果定义病例。

结果

每年送交 CL 实验室确认的病例数从 2007-2010 年的平均 77 ± 9 例增加到 2011 年的 178 例、2012 年的 327 例和 2013 年的 528 例。每年确认的 CL 阳性病例数分别从 36 ± 12 例增加到 117 例、171 例和 282 例，导致 CL 发病率（每 10 万人）分别从 5.8 ± 1.9 例增加到 18.4、26.3 和 42.7 例。暴发主要（>60%）发生在该地区的西北部。