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松树皮提取物对顺铂诱导的大鼠肝毒性和氧化应激的保护作用。

Protective effects of pine bark extract against cisplatin-induced hepatotoxicity and oxidative stress in rats.

作者信息

Ko Je-Won, Lee In-Chul, Park Sung-Hyuk, Moon Changjong, Kang Seong-Soo, Kim Sung-Ho, Kim Jong-Choon

机构信息

College of Veterinary Medicine, Chonnam National University, Gwangju, Korea.

出版信息

Lab Anim Res. 2014 Dec;30(4):174-80. doi: 10.5625/lar.2014.30.4.174. Epub 2014 Dec 24.

DOI:10.5625/lar.2014.30.4.174
PMID:25628728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4306705/
Abstract

We investigated the protective effects of pine bark extract (pycnogenol®, PYC) against cisplatin-induced hepatotoxicity and oxidative stress in rats. Twenty-four male rats were divided into the following four groups: (1) vehicle control, (2) cisplatin (7.5 mg/kg), (3) cisplatin & PYC 10 (10 mg/kg/day), and (4) cisplatin & PYC 20 (20 mg/kg/day). A single intraperitoneal injection of cisplatin induced hepatotoxicity, as evidenced by an increase in serum aminotransferase and histopathological alterations, including degeneration/necrosis of hepatocytes, vacuolation, and sinusoidal dilation. In addition, an increase in the malondialdehyde (MDA) concentration and a decrease in the reduced glutathione (GSH) content and catalase (CAT), superoxide dismutase (SOD), and glutathione S-transferase (GST) activities were observed in the cisplatin-treated rat hepatic tissues. In contrast, PYC treatment effectively prevented cisplatin-induced hepatotoxicity, including the elevation of aminotransferase and histopathological lesions, in a dosedependent manner. Moreover, PYC treatment also induced antioxidant activity by decreasing MDA level and increasing GSH content and SOD and GST activities in liver tissues. These results indicate that PYC has a protective effect against acute hepatotoxicity induced by cisplatin in rats, and that the protective effects of PYC may be due to inhibiting lipid peroxidation and increasing antioxidant activity.

摘要

我们研究了松树皮提取物（碧萝芷®，PYC）对顺铂诱导的大鼠肝毒性和氧化应激的保护作用。将24只雄性大鼠分为以下四组：（1）溶剂对照组，（2）顺铂组（7.5毫克/千克），（3）顺铂+PYC 10组（10毫克/千克/天），以及（4）顺铂+PYC 20组（20毫克/千克/天）。单次腹腔注射顺铂可诱导肝毒性，血清氨基转移酶升高及组织病理学改变（包括肝细胞变性/坏死、空泡化和肝血窦扩张）可证明这一点。此外，在顺铂处理的大鼠肝组织中观察到丙二醛（MDA）浓度升高，还原型谷胱甘肽（GSH）含量及过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽S-转移酶（GST）活性降低。相比之下，PYC处理以剂量依赖的方式有效预防了顺铂诱导的肝毒性，包括氨基转移酶升高和组织病理学损伤。此外，PYC处理还通过降低肝组织中的MDA水平、增加GSH含量以及SOD和GST活性诱导抗氧化活性。这些结果表明，PYC对顺铂诱导的大鼠急性肝毒性具有保护作用，且PYC的保护作用可能归因于抑制脂质过氧化和增加抗氧化活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40d/4306705/91d18ade9c62/lar-30-174-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40d/4306705/0a584d9e7eba/lar-30-174-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40d/4306705/0e6b95f40406/lar-30-174-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40d/4306705/91d18ade9c62/lar-30-174-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40d/4306705/0a584d9e7eba/lar-30-174-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40d/4306705/0e6b95f40406/lar-30-174-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f40d/4306705/91d18ade9c62/lar-30-174-g003.jpg

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