Jeung Yi Jo, Ok Hee Jae, Kim Won Gyu, Kim Sung Han, Lee Tae Hwa
Department of Obstetrics and Gynecology, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.
Obstet Gynecol Sci. 2015 Jan;58(1):32-9. doi: 10.5468/ogs.2015.58.1.32. Epub 2015 Jan 16.
The aim of this study is to compare the each clinical manifestation related with its mean survival time of Krukenberg tumors (KTs) of gastric origin versus with that of colorectal origin.
A total of 156 consecutive patients diagnosed with KTs of the ovary who underwent surgical treatment at a single institution between 2001 and 2010 were retrospectively evaluated. Each clinical manifestation related with its mean survival time compared two different groups. Survival analyses and comparisons were performed using the Kaplan-Meier method.
Among the 156 patients with KT, 111 patients with KTs of gastric origin and 45 patients with KTs of colorectal origin were identified. For all patients with KTs, median survival time was 22.7 months. Each mean survival time among all patients with KTs of gastric origin and colorectal origin was 19.2 months and 27.3 months. The results showed that mean survival time of postmenopausal patients was 19.0 months compared with 32.5 months for premenopausal patients (P=0.015). Among all patients, mean survival time of those with metachronous cancer was longer than those with synchronous cancer (P=0.001). In all cases, especially when only one ovary was invaded, the mean survival time was relatively higher (P=0.001).
Patients with KTs of colorectal origin had a better prognosis than those of gastric origin. In all cases of KT, the mean survival time was significantly longer in postmenoposal patients, metachronous disease and unilateral ovarian involvement. Notably, synchronous, ascites positive, and ovary only metastasis showed more longer mean survival time in the KTs of colorectal origin than KTs of gastric origin.
本研究旨在比较胃源性与结直肠源性库肯勃瘤（KTs）的各临床表现及其平均生存时间。
回顾性评估2001年至2010年间在单一机构接受手术治疗的156例连续诊断为卵巢KTs的患者。将各临床表现与其平均生存时间进行比较，分为两个不同组。采用Kaplan-Meier法进行生存分析和比较。
在156例KT患者中，确定了111例胃源性KT患者和45例结直肠源性KT患者。所有KT患者的中位生存时间为22.7个月。胃源性和结直肠源性KT患者的平均生存时间分别为19.2个月和27.3个月。结果显示，绝经后患者的平均生存时间为19.0个月，而绝经前患者为32.5个月（P=0.015）。在所有患者中，异时性癌患者的平均生存时间长于同时性癌患者（P=0.001）。在所有病例中，尤其是仅一侧卵巢受侵时，平均生存时间相对较长（P=0.001）。
结直肠源性KT患者的预后优于胃源性患者。在所有KT病例中，绝经后患者、异时性疾病和单侧卵巢受累患者的平均生存时间明显更长。值得注意的是，在结直肠源性KT中，同时性、腹水阳性和仅卵巢转移的患者平均生存时间比胃源性KT患者更长。
