State Key Laboratory of Animal Nutrition, China Agricultural University, No. 2, Yuanmingyuan West Road, Beijing 100193, China.
Pathogens. 2015 Jan 27;4(1):34-45. doi: 10.3390/pathogens4010034.
As the resistance of pathogens to antibiotics and the possibility of antibiotic residues in animal products attract increasing attention, the interest in the use of alternatives to in-feed antibiotics has been growing. Recent research with Lactic acid bacteria (LAB) in pigs suggests that LAB provide a potential alternative to antibiotic strategies. LAB include Lactobacillus species, Bifidobacterium spp, Bacillus spp, and some other microbes. LAB can adjust the intestinal environment, inhibit or kill pathogens in the gastrointestinal tract and improve the microbial balance in the intestine, as well as regulate intestinal mucosal immunity and maintain intestinal barrier function, thereby benefiting the health of pigs. The related mechanisms for these effects of LAB may include producing microbicidal substances with effects against gastrointestinal pathogens and other harmful microbes, competing with pathogens for binding sites on the intestinal epithelial cell surface and mucin as well as stimulating the immune system. In this review, the characteristics of LAB and their probiotic effects in newborn piglets, weaned piglets, growing pigs and sows are documented.
随着病原体对抗生素的耐药性和动物产品中抗生素残留的可能性引起越来越多的关注，人们对替代饲料抗生素的使用兴趣日益增长。最近在猪身上使用乳酸菌（LAB）的研究表明，LAB 为抗生素策略提供了一种潜在的替代方法。LAB 包括乳杆菌属、双歧杆菌属、芽孢杆菌属和其他一些微生物。LAB 可以调节肠道环境，抑制或杀死胃肠道中的病原体，改善肠道内的微生物平衡，以及调节肠道黏膜免疫和维持肠道屏障功能，从而有益于猪的健康。LAB 产生这些作用的相关机制可能包括产生对胃肠道病原体和其他有害微生物有杀菌作用的物质，与病原体竞争在肠上皮细胞表面和粘蛋白上的结合位点，并刺激免疫系统。在这篇综述中，记录了 LAB 的特性及其在新生仔猪、断奶仔猪、生长猪和母猪中的益生菌作用。
