一株匈牙利犬G3P[3] A组轮状病毒的全基因组测序显示，其与一株历史悠久的意大利人源毒株具有高度的遗传相关性。
Full-genome sequencing of a Hungarian canine G3P[3] Rotavirus A strain reveals high genetic relatedness with a historic Italian human strain.
作者信息
Papp H, Mihalov-Kovács E, Dóró R, Marton S, Farkas S L, Giammanco G M, De Grazia S, Martella V, Bányai K
机构信息
Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Hungária krt. 21, Budapest, 1143, Hungary.
出版信息
Virus Genes. 2015 Apr;50(2):310-5. doi: 10.1007/s11262-014-1163-8. Epub 2015 Jan 30.
A canine Rotavirus A strain was identified in the fecal specimen of a young dog during 2012 in Hungary. The strain RVA/Dog-wt/HUN/135/2012/G3P[3] shared complete genotype constellation (G3-P[3]-I3-R3-C3-M3-A15-N2-T3-E3-H6) and high genome sequence similarity (nt, 98.8 %) with a historic human strain, RVA/Human-tc/ITA/PA260-97/1997/G3P[3]. This study provides evidence for the canine origin of the unusual NSP1 genotype, A15, and reinforces the hypothesis of direct interspecies transmission of canine rotaviruses to humans.
2012年在匈牙利，从一只幼犬的粪便样本中鉴定出一株犬轮状病毒A。毒株RVA/Dog-wt/HUN/135/2012/G3P[3]与一株历史悠久的人源毒株RVA/Human-tc/ITA/PA260-97/1997/G3P[3]共享完整的基因型组合（G3-P[3]-I3-R3-C3-M3-A15-N2-T3-E3-H6），且基因组序列相似度高（核苷酸，98.8%）。本研究为不寻常的NSP1基因型A15的犬源提供了证据，并强化了犬轮状病毒直接跨物种传播给人类的假说。
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