Margolis Leonid
Eunice Kennedy-Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md.
Am J Med. 2015 Jun;128(6):562-6. doi: 10.1016/j.amjmed.2014.12.026. Epub 2015 Jan 28.
It is becoming increasingly clear that immunoactivation, which evolved as a system of host defense against pathogens, can become dysregulated and promote the pathogenesis of diverse diseases with both known and unknown etiologies (eg, acquired immune deficiency syndrome, age-related macular degeneration, cancer, as well as aging). Immunoactivation seems to be a "common denominator" or general mechanism of pathogenesis and may explain the association and similarities in pathology among otherwise unrelated human diseases. Identification of general mechanisms of immunoactivation may lead to the development of new therapeutic strategies applicable to many diseases even before detailed knowledge of specific etiology and pathogenesis may be available.
越来越明显的是，免疫激活作为一种抵御病原体的宿主防御系统，可能会失调，并促进各种病因已知和未知的疾病的发病机制（例如，获得性免疫缺陷综合征、年龄相关性黄斑变性、癌症以及衰老）。免疫激活似乎是发病机制的“共同特征”或一般机制，可能解释了原本不相关的人类疾病在病理学上的关联和相似性。即使在尚未详细了解具体病因和发病机制之前，确定免疫激活的一般机制可能会导致开发适用于多种疾病的新治疗策略。
