Schall Ulrich, Müller Bernhard W, Kärgel Christian, Güntürkün Onur
aPriority Centre for Translational Neuroscience & Mental Health Research, The University of Newcastle, Callaghan bSchizophrenia Research Institute, Sydney cHunter Medical Research Institute, New Lambton, Australia dDepartment of Psychology, University of Wuppertal, Wuppertal eDepartment of Psychiatry and Psychotherapy, Faculty of Medicine, LVR-Hospital Essen fInstitute of Forensic Psychiatry, Faculty of Medicine, University of Duisburg-Essen, Essen gInstitute of Cognitive Neuroscience, Division of Biological Psychology, Ruhr-University of Bochum, Bochum, Germany.
Neuroreport. 2015 Mar 25;26(5):239-44. doi: 10.1097/WNR.0000000000000323.
The neural response to occasional variations in acoustic stimuli in a regular sequence of sounds generates an N-methyl-D-aspartate receptor-modulated event-related potential in primates and rodents in the primary auditory cortex known as mismatch negativity (MMN). The current study investigated MMN in pigeons (Columba livia L) through intracranial recordings from Field L of the caudomedial nidopallium, the avian functional equivalent of the mammalian primary auditory cortex. Auditory evoked field potentials were recorded from awake birds using a low-frequency (800 Hz) and high-frequency (1400 Hz) deviant auditory oddball procedure with deviant-as-standard (flip-flop design) and multiple-standard control conditions. An MMN-like field potential was recorded and blocked with systemic 5 mg/kg ketamine administration. Our results are similar to human and rodent findings of an MMN-like event-related potential in birds suggestive of similar auditory sensory memory mechanisms in birds and mammals that are homologue from a common ancestor 300 million years ago or resulted from convergent evolution.
在灵长类动物和啮齿动物的初级听觉皮层中，对规则声音序列中偶尔出现的声学刺激变化的神经反应会产生一种由N-甲基-D-天冬氨酸受体调节的事件相关电位，称为失配负波（MMN）。本研究通过对家鸽（Columba livia L）脑内侧巢皮质L区进行颅内记录来研究MMN，该区域相当于哺乳动物初级听觉皮层的鸟类功能对应区域。使用低频（800赫兹）和高频（1400赫兹）偏差听觉oddball程序，在偏差-标准（触发器设计）和多标准对照条件下从清醒鸟类记录听觉诱发电位场。记录到了一种类似MMN的场电位，并通过全身注射5毫克/千克氯胺酮将其阻断。我们的结果与人类和啮齿动物的研究结果相似，即在鸟类中发现了类似MMN的事件相关电位，这表明鸟类和哺乳动物具有相似的听觉感觉记忆机制，这些机制要么源于3亿年前共同祖先的同源性，要么是趋同进化的结果。
