Björk J, Kleinau S, Tengblad A, Smedegård G
Department of Inflammation Research, Pharmacia LEO Therapeutics AB, Uppsala, Sweden.
Arthritis Rheum. 1989 Mar;32(3):306-11. doi: 10.1002/anr.1780320312.
The serum hyaluronate (HA) concentration was measured in groups of rats immunized for adjuvant or type II collagen arthritis. Serum HA increased as the arthritic lesions developed, correlating with the severity of the disease. This increase in HA was not related to metabolic impairment, because rats with adjuvant arthritis metabolized intravenously administered tritiated HA at a rate similar to that of normal rats. Serum HA levels may be useful as an indicator of synovitis in experimental and possibly in clinical arthritis. Further, this model could serve as an experimental approach for studies of HA metabolism in chronic joint inflammation.
在接受佐剂或II型胶原性关节炎免疫的大鼠组中测量血清透明质酸（HA）浓度。随着关节炎病变的发展，血清HA升高，与疾病的严重程度相关。HA的这种升高与代谢损伤无关，因为佐剂性关节炎大鼠静脉注射氚标记的HA的代谢速率与正常大鼠相似。血清HA水平可用作实验性关节炎以及可能的临床关节炎中滑膜炎的指标。此外，该模型可作为研究慢性关节炎症中HA代谢的实验方法。
