细胞代谢与癌症中的自噬
Autophagy in cellular metabolism and cancer.
作者信息
Jiang Xuejun, Overholtzer Michael, Thompson Craig B
出版信息
J Clin Invest. 2015 Jan;125(1):47-54. doi: 10.1172/JCI73942. Epub 2015 Jan 2.
Abstract
Autophagy is a catabolic process mediated by incorporation of cellular material into cytosolic membrane vesicles for lysosomal degradation. It is crucial for maintaining cell viability and homeostasis in response to numerous stressful conditions. In this Review, the role of autophagy in both normal biology and disease is discussed. Emphasis is given to the interplay of autophagy with nutrient signaling through the ULK1 autophagy pre-initiation complex. Furthermore, related cellular processes utilizing components of the canonical autophagy pathway are discussed due to their potential roles in nutrient scavenging. Finally, the role of autophagy in cancer and its potential as a cancer therapeutic target are considered.
摘要
自噬是一种分解代谢过程，通过将细胞物质纳入胞质膜泡以进行溶酶体降解来介导。它对于在应对多种应激条件时维持细胞活力和内环境稳定至关重要。在本综述中，讨论了自噬在正常生物学和疾病中的作用。重点阐述了自噬与通过ULK1自噬预启动复合物的营养信号传导之间的相互作用。此外，还讨论了利用经典自噬途径成分的相关细胞过程，因为它们在营养清除中具有潜在作用。最后，考虑了自噬在癌症中的作用及其作为癌症治疗靶点的潜力。
相似文献
1
Autophagy in cellular metabolism and cancer.
J Clin Invest. 2015 Jan;125(1):47-54. doi: 10.1172/JCI73942. Epub 2015 Jan 2.
2
UNC51-like kinase 1, autophagic regulator and cancer therapeutic target.
Cell Prolif. 2014 Dec;47(6):494-505. doi: 10.1111/cpr.12145. Epub 2014 Oct 20.
3
Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.
Bioorg Med Chem. 2015 Sep 1;23(17):5483-8. doi: 10.1016/j.bmc.2015.07.034. Epub 2015 Jul 26.
4
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Autophagy. 2015;11(9):1458-70. doi: 10.1080/15548627.2015.1067359.
5
The serine/threonine kinase ULK1 is a target of multiple phosphorylation events.
Biochem J. 2011 Dec 1;440(2):283-91. doi: 10.1042/BJ20101894.
6
Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells.
FEBS J. 2014 Oct;281(20):4644-58. doi: 10.1111/febs.12969. Epub 2014 Sep 11.
7
Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy.
Redox Biol. 2015;4:184-92. doi: 10.1016/j.redox.2014.12.003. Epub 2014 Dec 10.
8
Chaperone-like protein p32 regulates ULK1 stability and autophagy.
Cell Death Differ. 2015 Nov;22(11):1812-23. doi: 10.1038/cdd.2015.34. Epub 2015 Apr 23.
9
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
Oncotarget. 2015 Dec 29;6(42):44941-54. doi: 10.18632/oncotarget.6759.
10
Unc-51 like kinase 1 (ULK1) in silico analysis for biomarker identification: a vital component of autophagy.
Gene. 2015 May 10;562(1):40-9. doi: 10.1016/j.gene.2015.02.056. Epub 2015 Feb 19.
引用本文的文献
1
Increased autophagy activity suppresses hyperglycemia-related colorectal cancer tumorigenesis both and .
Am J Cancer Res. 2025 Jul 15;15(7):2949-2969. doi: 10.62347/XSRQ4118. eCollection 2025.
2
Antioxidant Potential of Xanthohumol in Disease Prevention: Evidence from Human and Animal Studies.
Antioxidants (Basel). 2024 Dec 19;13(12):1559. doi: 10.3390/antiox13121559.
3
The role of autophagy in brain health and disease: Insights into exosome and autophagy interactions.
Heliyon. 2024 Oct 4;10(21):e38959. doi: 10.1016/j.heliyon.2024.e38959. eCollection 2024 Nov 15.
4
Unraveling the interplay between inflammation and stem cell mobilization or homing: Implications for tissue repair and therapeutics.
Tzu Chi Med J. 2024 Sep 5;36(4):349-359. doi: 10.4103/tcmj.tcmj_100_24. eCollection 2024 Oct-Dec.
5
The clinical significance of endoplasmic reticulum stress related genes in non-small cell lung cancer and analysis of single nucleotide polymorphism for CAV1.
Front Mol Biosci. 2024 Aug 6;11:1414164. doi: 10.3389/fmolb.2024.1414164. eCollection 2024.
6
Inflammation-Associated Cytotoxic Agents in Tumorigenesis.
Cancers (Basel). 2023 Dec 22;16(1):81. doi: 10.3390/cancers16010081.
7
NEDD4L in human tumors: regulatory mechanisms and dual effects on anti-tumor and pro-tumor.
Front Pharmacol. 2023 Nov 9;14:1291773. doi: 10.3389/fphar.2023.1291773. eCollection 2023.
8
JI017 Induces Cell Autophagy and Apoptosis via Elevated Levels of Reactive Oxygen Species in Human Lung Cancer Cells.
Int J Mol Sci. 2023 Apr 19;24(8):7528. doi: 10.3390/ijms24087528.
9
Selective Inhibitors of Autophagy Reveal New Link between the Cell Cycle and Autophagy and Lead to Discovery of Novel Synergistic Drug Combinations.
ACS Chem Biol. 2022 Dec 16;17(12):3290-3297. doi: 10.1021/acschembio.2c00710. Epub 2022 Dec 5.
10
Metabolic determinants of tumour initiation.
Nat Rev Endocrinol. 2023 Mar;19(3):134-150. doi: 10.1038/s41574-022-00773-5. Epub 2022 Nov 29.
本文引用的文献
1
Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.
Cancer Cell. 2014 Jul 14;26(1):121-135. doi: 10.1016/j.ccr.2014.05.004. Epub 2014 Jul 4.
2
Autophagy is required for glucose homeostasis and lung tumor maintenance.
Cancer Discov. 2014 Aug;4(8):914-27. doi: 10.1158/2159-8290.CD-14-0363. Epub 2014 May 29.
3
Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice.
Oncotarget. 2014 May 15;5(9):2761-77. doi: 10.18632/oncotarget.1942.
4
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
Nature. 2014 May 1;509(7498):105-9. doi: 10.1038/nature13148. Epub 2014 Mar 30.
5
Regulation of autophagy by cytosolic acetyl-coenzyme A.
Mol Cell. 2014 Mar 6;53(5):710-25. doi: 10.1016/j.molcel.2014.01.016. Epub 2014 Feb 20.
6
A dual role for autophagy in a murine model of lung cancer.
Nat Commun. 2014;5:3056. doi: 10.1038/ncomms4056.
7
The machinery of macroautophagy.
Cell Res. 2014 Jan;24(1):24-41. doi: 10.1038/cr.2013.168. Epub 2013 Dec 24.
8
Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing.
J Cell Biol. 2013 Dec 9;203(5):757-66. doi: 10.1083/jcb.201308173.
9
Autophagy-mediated tumor promotion.
Cell. 2013 Dec 5;155(6):1216-9. doi: 10.1016/j.cell.2013.11.019.
10
p53 status determines the role of autophagy in pancreatic tumour development.
Nature. 2013 Dec 12;504(7479):296-300. doi: 10.1038/nature12865. Epub 2013 Dec 4.
Zotero 插件