Jiang Xuejun, Overholtzer Michael, Thompson Craig B
J Clin Invest. 2015 Jan;125(1):47-54. doi: 10.1172/JCI73942. Epub 2015 Jan 2.
Autophagy is a catabolic process mediated by incorporation of cellular material into cytosolic membrane vesicles for lysosomal degradation. It is crucial for maintaining cell viability and homeostasis in response to numerous stressful conditions. In this Review, the role of autophagy in both normal biology and disease is discussed. Emphasis is given to the interplay of autophagy with nutrient signaling through the ULK1 autophagy pre-initiation complex. Furthermore, related cellular processes utilizing components of the canonical autophagy pathway are discussed due to their potential roles in nutrient scavenging. Finally, the role of autophagy in cancer and its potential as a cancer therapeutic target are considered.
自噬是一种分解代谢过程，通过将细胞物质纳入胞质膜泡以进行溶酶体降解来介导。它对于在应对多种应激条件时维持细胞活力和内环境稳定至关重要。在本综述中，讨论了自噬在正常生物学和疾病中的作用。重点阐述了自噬与通过ULK1自噬预启动复合物的营养信号传导之间的相互作用。此外，还讨论了利用经典自噬途径成分的相关细胞过程，因为它们在营养清除中具有潜在作用。最后，考虑了自噬在癌症中的作用及其作为癌症治疗靶点的潜力。
