Adrian T, Wigand R, Knocke K W, Schäfer G, Grundmann M
Abteilung für Virologie, Universitätskliniken Homburg (Saar), Federal Republic of Germany.
Arch Virol. 1989;105(1-2):89-101. doi: 10.1007/BF01311119.
Adenoviruses (AV), isolated from 138 children during the year 1981 in the Hannover area, were studied by DNA restriction analysis with the enzymes BamHI, BglII, BstEII, EcoRI, HindIII, KpnI, and SmaI and compared with the respective prototypes. Varying fragment patterns were depicted and genome types analyzed. Prototype-like strains of AV1 and 5 were not found. Types 2, 5, 1, 3, and 7 showed decreasing genetic variation in that order. Altered restriction sites were physically mapped on the genome; they appeared to be randomly distributed. The high genetic variability of AV2 and 5 is remarkable for this study population, limited in time and space. Clinical and epidemiological data were also presented in relation to serotypes.
1981年在汉诺威地区从138名儿童中分离出腺病毒（AV），用BamHI、BglII、BstEII、EcoRI、HindIII、KpnI和SmaI酶进行DNA限制酶切分析，并与各自的原型进行比较。描绘了不同的片段模式并分析了基因组类型。未发现AV1和5的原型样菌株。2型、5型、1型、3型和7型的遗传变异依次递减。改变的限制酶切位点在基因组上进行了物理定位；它们似乎是随机分布的。对于这个在时间和空间上有限的研究群体来说，AV2和5的高遗传变异性很显著。还给出了与血清型相关的临床和流行病学数据。
