Adrian T
Nationales Referenzzentrum für Adenoviren, Medizinische Hochschule Hannover, Federal Republic of Germany.
Arch Virol. 1996;141(6):1021-31. doi: 10.1007/BF01718606.
The genome of adenovirus (AV) types 1, 2, and 5 is known to be very variable as evidenced by the great number of genome types described (36, 61, and 35 for AV1, 2, and 5 respectively). Physical maps were constructed for nearly all of the restriction or R-variants by biochemical methods and by adapting restriction fragments of defined molecular weight. The alterations found with seven DNA restriction endonucleases were mapped on the genome. Altered restriction sites, found for the genome types of each of the three serotypes, appeared to be randomly distributed over the genome, although mutations seemed to occur preferentially on distinct sites of the genome. Many strains, especially those of AV5, were genomically much more related with one another than with the prototype. This finding is compatible with the interpretation that the related strains were derived from an unknown common ancestor.
已知1型、2型和5型腺病毒（AV）的基因组具有高度变异性，这一点从已描述的大量基因组类型中可见一斑（AV1、2和5分别有36种、61种和35种）。通过生化方法并采用特定分子量的限制性片段，为几乎所有的限制性或R变体构建了物理图谱。用七种DNA限制性内切酶发现的改变被定位在基因组上。在三种血清型各自的基因组类型中发现的限制性位点改变似乎随机分布在基因组上，尽管突变似乎优先发生在基因组的特定位点。许多毒株，尤其是AV5的毒株，在基因组上彼此之间的相关性比与原型毒株的相关性更高。这一发现与相关毒株源自未知共同祖先的解释相符。
