Falcone Tatiana, Janigro Damir, Lovell Rachel, Simon Barry, Brown Charles A, Herrera Mariela, Myint Aye Mu, Anand Amit
Cleveland Clinic, Neurologic Institute, Department of Neurology, 9500 Euclid Avenue, S60, Cleveland, OH 44195, USA; Cleveland Clinic, Neurologic Institute, Department of Psychiatry, 9500 Euclid Avenue, P57, Cleveland, OH 44195, USA.
Cleveland Clinic, Lerner College of Medicine, Cerebrovascular Research NB-20 LRI, 9600 Euclid Avenue, Cleveland, OH 44195, USA.
J Psychiatr Res. 2015 Mar;62:14-22. doi: 10.1016/j.jpsychires.2014.12.002. Epub 2014 Dec 25.
Serum levels of the astrocytic protein S100B have been reported to indicate disruption of the blood-brain barrier. In this study, we investigated the relationship between S100B levels and childhood trauma in a child psychiatric inpatient unit.
Levels of S100B were measured in a group of youth with mood disorders or psychosis with and without history of childhood trauma as well as in healthy controls. Study participants were 93 inpatient adolescents admitted with a diagnosis of psychosis (N = 67), or mood disorder (N = 26) and 22 healthy adolescents with no history of trauma or psychiatric illness. Childhood trauma was documented using the Life Events Checklist (LEC) and Adverse Child Experiences (ACE).
In a multivariate regression model, suicidality scores and trauma were the only two variables which were independently related to serum S100B levels. Patients with greater levels of childhood trauma had significantly higher S100B levels even after controlling for intensity of suicidal ideation. Patients with psychotic diagnoses and mood disorders did not significantly differ in their levels of S100B. Patients exposed to childhood trauma were significantly more likely to have elevated levels of S100B (p < .001) than patients without trauma, and patients with trauma had significantly higher S100B levels (p < .001) when compared to the control group. LEC (p = 0.046), and BPRS-C suicidality scores (p = 0.001) significantly predicted S100B levels.
Childhood trauma can potentially affect the integrity of the blood-brain barrier as indicated by associated increased S100B levels.
据报道，星形细胞蛋白S100B的血清水平可表明血脑屏障的破坏。在本研究中，我们调查了儿童精神科住院病房中S100B水平与童年创伤之间的关系。
对一组有或无童年创伤史的患有情绪障碍或精神病的青少年以及健康对照者测量S100B水平。研究参与者为93名住院青少年，其中67名被诊断为精神病，26名被诊断为情绪障碍，另有22名无创伤史或精神疾病史的健康青少年。使用生活事件清单（LEC）和儿童不良经历（ACE）记录童年创伤。
在多变量回归模型中，自杀倾向得分和创伤是仅有的两个与血清S100B水平独立相关的变量。即使在控制自杀意念强度后，童年创伤程度较高的患者的S100B水平仍显著更高。患有精神病诊断和情绪障碍的患者的S100B水平没有显著差异。与无创伤的患者相比，经历童年创伤的患者S100B水平升高的可能性显著更高（p <.001），与对照组相比，有创伤的患者S100B水平显著更高（p <.001）。LEC（p = 0.046）和简明精神病评定量表自杀倾向得分（p = 0.001）显著预测S100B水平。
如S100B水平升高所示，童年创伤可能会影响血脑屏障的完整性。
