Luc Raymond, Tortorella Stephanie M, Ververis Katherine, Karagiannis Tom C
Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, 75 Commercial Road, Melbourne, VIC, Australia.
Mol Biol Rep. 2015 Apr;42(4):835-40. doi: 10.1007/s11033-015-3859-9.
Although oncogenetics remains a critical component of cancer biology and therapeutic research, recent interest has been taken towards the non-genetic features of tumour development and progression, such as cancer metabolism. Specifically, it has been observed that tumour cells are inclined to preferentially undergo glycolysis despite presence of adequate oxygen. First reported by Otto Warburg in the 1920s, and now termed the 'Warburg effect', this aberrant metabolism has become of particular interest due to the prevalence of the fermentation phenotype in a variety of cancers studied. Consequently, this phenotype has proven to play a pivotal role in cancer proliferation. As such Warburg's observations are now being integrated within the modern paradigms of cancer and in this review we explore the role of lactate as an insidious metabolite due to the Warburg effect.
尽管肿瘤遗传学仍是癌症生物学和治疗研究的关键组成部分，但最近人们对肿瘤发生和进展的非遗传特征产生了兴趣，比如癌症代谢。具体而言，已观察到肿瘤细胞即便在有充足氧气的情况下也倾向于优先进行糖酵解。这一异常代谢最早由奥托·瓦尔堡在20世纪20年代报道，现在被称为“瓦尔堡效应”，由于在所研究的多种癌症中发酵表型普遍存在，它已变得格外引人关注。因此，这种表型已被证明在癌症增殖中起关键作用。鉴于此，瓦尔堡的观察结果目前正被纳入现代癌症范式中，在本综述中，我们探讨乳酸作为瓦尔堡效应导致的一种隐匿性代谢产物所起的作用。
