State Key Laboratory of Natural and Biomimetic Drugs, Peking University , Beijing 100191, P.R. China.
Org Lett. 2015 Mar 6;17(5):1220-3. doi: 10.1021/acs.orglett.5b00172. Epub 2015 Feb 12.
Two new peptaibols, namely microbacterins A (1) and B (2), were isolated from the deep sea inhabited actinomycete Microbacterium sediminis spp. nov. YLB-01(T). The sequences of the amino acid residues were determined on the basis of intensive NMR and ESI-MS/MS spectroscopic analysis, in addition to the Marfey's method and CD and optical rotation data for the configurational assignment. Both 1 and 2 exhibited significant cytotoxic activities against a panel of human tumor cell lines.
两种新的缩肽类化合物，即 microbacterins A（1）和 B（2），从深海栖居放线菌 Microbacterium sediminis spp. nov. YLB-01(T)中分离得到。氨基酸残基序列是基于密集的 NMR 和 ESI-MS/MS 光谱分析，以及 Marfey 方法和 CD 及旋光数据确定的，用于构型分配。1 和 2 均对一组人类肿瘤细胞系表现出显著的细胞毒性活性。
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