Stensvold Dorthe, Viken Hallgeir, Rognmo Øivind, Skogvoll Eirik, Steinshamn Sigurd, Vatten Lars J, Coombes Jeff S, Anderssen Sigmund A, Magnussen Jon, Ingebrigtsen Jan Erik, Fiatarone Singh Maria A, Langhammer Arnulf, Støylen Asbjørn, Helbostad Jorunn L, Wisløff Ulrik
KG Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
BMJ Open. 2015 Feb 12;5(2):e007519. doi: 10.1136/bmjopen-2014-007519.
Epidemiological studies suggest that exercise has a tremendous preventative effect on morbidity and premature death, but these findings need to be confirmed by randomised trials. Generation 100 is a randomised, controlled study where the primary aim is to evaluate the effects of 5 years of exercise training on mortality in an elderly population.
All men and women born in the years 1936-1942 (n=6966), who were residents of Trondheim, Norway, were invited to participate. Between August 2012 and June 2013, a total of 1567 individuals (790 women) were included and randomised to either 5 years of two weekly sessions of high-intensity training (10 min warm-up followed by 4×4 min intervals at ∼90% of peak heart rate) or, moderate-intensity training (50 min of continuous work at ∼70% of peak heart rate), or to a control group that followed physical activity advice according to national recommendations. Clinical examinations, physical tests and questionnaires will be administered to all participants at baseline, and after 1, 3 and 5 years. Participants will also be followed up by linking to health registries until year 2035.
The study has been conducted according to the SPIRIT statement. All participants signed a written consent form, and the study has been approved by the Regional Committee for Medical Research Ethics, Norway. Projects such as this are warranted in the literature, and we expect that data from this study will result in numerous papers published in world-leading clinical journals; we will also present the results at international and national conferences.
Clinicaltrials.gov NCT01666340.
流行病学研究表明，运动对发病率和过早死亡具有巨大的预防作用，但这些发现需要通过随机试验来证实。“100代人”研究是一项随机对照研究，其主要目的是评估5年运动训练对老年人群死亡率的影响。
邀请了所有1936年至1942年出生（n = 6966）、居住在挪威特隆赫姆的男性和女性参与研究。在2012年8月至2013年6月期间，共纳入了1567名个体（790名女性），并将其随机分为三组：一组接受为期5年、每周两次的高强度训练（10分钟热身，随后是4组每组4分钟的间隔训练，心率约为峰值心率的90%）；一组接受中等强度训练（持续50分钟的运动，心率约为峰值心率的70%）；另一组为对照组，按照国家建议接受体育活动指导。在基线、1年、3年和5年后，将对所有参与者进行临床检查、体能测试和问卷调查。参与者还将通过与健康登记处建立联系进行随访，直至2035年。
本研究遵循SPIRIT声明进行。所有参与者均签署了书面同意书，该研究已获得挪威医学研究伦理区域委员会的批准。文献中对这类项目是有需求的，我们预计本研究的数据将产生大量发表在世界领先临床期刊上的论文；我们还将在国际和国内会议上展示研究结果。
Clinicaltrials.gov NCT01666340
