Gan Hongjian, He Haiwen, Sato Atsushi, Hatta Hajime, Nakao Miki, Somamoto Tomonori
Laboratory of Marine Biochemistry, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Kyorin Co. Ltd., 9 Minami-machi, Himeji, Hyogo, Japan.
Res Vet Sci. 2015 Apr;99:82-6. doi: 10.1016/j.rvsc.2015.01.016. Epub 2015 Feb 3.
Ulcer disease, caused by atypical Aeromonas salmonicida, is a serious concern in ornamental koi carp, because it induces skin ulceration, disfiguring ornamental fish and causing economic loses. The present study aimed to establish a novel prophylaxis with chicken egg yolk immunoglobulin, IgY, against ulcer disease and to assess its feasibility in the ornamental fish industry. Addition of egg yolk powder containing anti-A. salmonicida IgY to rearing water provided significant protection against an A. salmonicida bath infection, whereas administration of non-specific IgY did not. Consecutive immersion of fish into rearing water containing specific IgY completely prevented ulcer disease resulting from cohabitation infection, indicating that this prophylaxis could prevent infection from such type of contact. Thus, passive immunization induced by immersing fish into aquarium water containing specific IgY is a prospective prophylaxis against diseases caused by pathogens that invade the skin and gills.
由非典型杀鲑气单胞菌引起的溃疡病是观赏锦鲤养殖中的一个严重问题,因为它会导致皮肤溃疡,使观赏鱼外形受损并造成经济损失。本研究旨在建立一种用鸡卵黄免疫球蛋白(IgY)预防溃疡病的新方法,并评估其在观赏鱼产业中的可行性。在养殖水中添加含有抗杀鲑气单胞菌IgY的蛋黄粉可有效预防杀鲑气单胞菌的浸浴感染,而给予非特异性IgY则无此效果。将鱼连续浸入含有特异性IgY的养殖水中可完全预防同居感染引起的溃疡病,这表明这种预防方法可以防止此类接触感染。因此,将鱼浸入含有特异性IgY的水族箱水中诱导的被动免疫是预防由侵入皮肤和鳃的病原体引起的疾病的一种有前景的预防方法。