体外高脂血症兔主动脉靶向早期动脉粥样硬化变化的血管内磁动力光学相干断层扫描
Intravascular magnetomotive optical coherence tomography of targeted early-stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas.
作者信息
Kim Jongsik, Ahmad Adeel, Li Joanne, Marjanovic Marina, Chaney Eric J, Suslick Kenneth S, Boppart Stephen A
出版信息
J Biophotonics. 2016 Jan;9(1-2):109-16. doi: 10.1002/jbio.201400128.
Abstract
We report the development of an intravascular magnetomotive optical coherence tomography (IV-MM-OCT) system used with targeted protein microspheres to detect early-stage atherosclerotic fatty streaks/plaques. Magnetic microspheres (MSs) were injected in vivo in rabbits, and after 30 minutes of in vivo circulation, excised ex vivo rabbit aorta samples specimens were then imaged ex vivo with our prototype IV-MM-OCT system. The alternating magnetic field gradient was provided by a unique pair of external custom-built electromagnetic coils that modulated the targeted magnetic MSs. The results showed a statistically significant MM-OCT signal from the aorta samples specimens injected with targeted MSs.
摘要
我们报告了一种血管内磁动光相干断层扫描（IV-MM-OCT）系统的研发情况，该系统与靶向蛋白微球配合使用，用于检测早期动脉粥样硬化脂肪条纹/斑块。将磁性微球（MSs）注射到兔体内，在体内循环30分钟后，取出兔主动脉样本标本，然后用我们的IV-MM-OCT系统原型进行离体成像。交变磁场梯度由一对独特的外部定制电磁线圈提供，该线圈可调制靶向磁性微球。结果显示，注射了靶向微球的主动脉样本标本有统计学上显著的MM-OCT信号。
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