Surface Science Research Centre, University of Liverpool, Liverpool, UK.
Future Microbiol. 2015;10(2):255-72. doi: 10.2217/fmb.14.109.
The biostimulative effect of low-level laser therapy (LLLT) in tissues has been noted in reference to the treatment of various diseases but little information exists on its effectiveness on chronic wounds and biofilm. The scope of this review was to identify literature reporting on LLLT alone, without photodynamic agents, as an antimicrobial/antibiofilm technology and determine its effects on wound healing. Overall the beneficial effects of LLLT in promoting wound healing in animal and human studies has been demonstrated. However, the lack of credible studies using reproducible models and light dosimetry restricts the analysis of current data. Efforts must be addressed to standardize phototherapy procedures as well as to develop suitable in vitro and in vivo biofilm models to test LLLT efficacy in promoting biofilm eradication and wound healing.
低水平激光疗法（LLLT）在组织中的生物刺激作用已在治疗各种疾病方面得到了关注，但关于其在慢性创面和生物膜方面的有效性的信息却很少。本综述的范围是确定仅报告 LLLT 的文献，不包括光动力剂，作为一种抗菌/抗生物膜技术，并确定其对创面愈合的影响。总的来说，已经证明了 LLLT 在促进动物和人类创面愈合方面的有益作用。然而，由于缺乏使用可重复模型和光剂量学的可信研究，限制了对当前数据的分析。必须努力使光疗程序标准化，并开发合适的体外和体内生物膜模型，以测试 LLLT 促进生物膜清除和创面愈合的功效。
