大鼠脑中生长抑素水平及生长抑素结合的年龄依赖性

Age dependence of somatostatin levels and somatostatin binding in the rat brain.

Sirviö J, Jolkkonen J, Pitkänen A, Riekkinen P J

Comp Biochem Physiol A Comp Physiol. 1987;87(2):355-7. doi: 10.1016/0300-9629(87)90135-6.

Abstract

Somatostatin-like immunoreactivity (SLI) and 125I-Tyrl-somatostatin binding were measured from the brains of rats aged 1, 8 and 18 months. 2. Somatostatin binding was reduced in the striatum, frontal cortex, hypothalamus and hippocampus of the 8-month-old rats compared to the 1-month-old group. 3. Somatostatin binding was reduced in the striatum, frontal cortex and hippocampus of the 18-month-old rats compared to the 1-month-old group. 4. The reduction (40%) was most striking in the frontal cortex. 5. In no area of the brain did changes in SLI differ significantly between the different age groups.

摘要

对1个月、8个月和18个月大的大鼠大脑进行了生长抑素样免疫反应性（SLI）和¹²⁵I-酪氨酰-生长抑素结合的检测。2. 与1个月大的组相比，8个月大的大鼠纹状体、额叶皮质、下丘脑和海马体中的生长抑素结合减少。3. 与1个月大的组相比，18个月大的大鼠纹状体、额叶皮质和海马体中的生长抑素结合减少。4. 额叶皮质中的减少（40%）最为显著。5. 不同年龄组之间，大脑的任何区域中SLI的变化均无显著差异。