伊朗大不里士糖尿病足感染的细菌病因及抗生素敏感性模式
Bacterial etiology and antibiotic susceptibility pattern of diabetic foot infections in Tabriz, Iran.
作者信息
Akhi Mohammad Taghi, Ghotaslou Reza, Asgharzadeh Mohammad, Varshochi Mojtaba, Pirzadeh Tahereh, Memar Mohammad Yousef, Zahedi Bialvaei Abed, Seifi Yarijan Sofla Hasan, Alizadeh Naser
机构信息
Research Center of Infectious and Tropical Disease, Tabriz University of Medical Sciences, Tabriz, Iran ; Department of Bacteriology and Virology, School of Medicine, Tabriz University of Medical Sciences, Iran.
Department of Bacteriology and Virology, School of Medicine, Tabriz University of Medical Sciences, Iran.
出版信息
GMS Hyg Infect Control. 2015 Feb 2;10:Doc02. doi: 10.3205/dgkh000245. eCollection 2015.
AIM
The aim of this study was to investigate anaerobic and aerobic bacteria profile and determination of antibiotic susceptibility pattern in aerobic bacteria.
METHOD
Specimens were cultured using optimal aerobic and anaerobic microbiological techniques. Identification of bacterial isolates was performed by standard microbiological methods and antibiotic susceptibility testing was performed according to the guidelines of Clinical and Laboratory Standards Institute (CLSI).
RESULT
92 bacterial strains were isolated from 60 samples of diabetic foot ulcers. Predominant aerobic bacteria isolated from these infections were S. aureus (28%) followed by Enterobacteriaceae family (24%) including Escherichia coli (15%), Citrobacter spp. (4%), Enterobacter spp. (4%), and coagulase-negative Staphylococcus spp. (17%), Enterococcus spp. (15%), Pseudomonas aeruginosa (7%) and Acinetobacter spp. (4%). No Clostridium spp. were isolated and 4% Bacteroides fragilis obtained from anaerobic culture. All Gram-positive isolates were susceptible to linezolid while all Enterobacteriaceae showed sensitivity to imipenem.
CONCLUSION
Most of DFIs specimens were poly microbial infection and predominant bacteria were S. aureus and B. fragilis. These wounds may require use of combined antimicrobial therapy for initial management.
目的
本研究旨在调查需氧菌和厌氧菌的菌谱，并确定需氧菌的抗生素敏感性模式。
方法
采用最佳的需氧和厌氧微生物技术对标本进行培养。通过标准微生物学方法对分离出的细菌进行鉴定，并根据临床和实验室标准协会（CLSI）的指南进行抗生素敏感性测试。
结果
从60份糖尿病足溃疡样本中分离出92株细菌。从这些感染中分离出的主要需氧菌是金黄色葡萄球菌（28%），其次是肠杆菌科（24%），包括大肠杆菌（15%）、柠檬酸杆菌属（4%）、肠杆菌属（4%），凝固酶阴性葡萄球菌属（17%）、肠球菌属（15%）、铜绿假单胞菌（7%）和不动杆菌属（4%）。未分离出梭菌属，厌氧培养获得4%脆弱拟杆菌。所有革兰氏阳性菌分离株对利奈唑胺敏感，而所有肠杆菌科细菌对亚胺培南敏感。
结论
大多数糖尿病足感染标本为混合感染，主要细菌是金黄色葡萄球菌和脆弱拟杆菌。这些伤口在初始治疗时可能需要联合使用抗菌疗法。
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