缺乏D-氨基酸氧化酶的突变小鼠尿液中D-丙氨酸的自发排泄
Spontaneous excretion of D-alanine in urine in mutant mice lacking D-amino-acid oxidase.
作者信息
Konno R, Nagata Y, Niwa A, Yasumura Y
机构信息
Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan.
出版信息
Biochem J. 1989 Jul 1;261(1):285-7. doi: 10.1042/bj2610285.
Abstract
Urine from mutant mice lacking D-amino-acid oxidase contained a large amount of alanine compared with that from normal mice. Urinary alanine of the mutant mice was sensitive to D-amino-acid oxidase. H.p.l.c. showed that about 94% of the urinary alanine had the D-configuration. These results suggest that D-amino-acid oxidase functions to decompose D-amino acid(s) in normal mice.
摘要
与正常小鼠相比，缺乏D-氨基酸氧化酶的突变小鼠尿液中含有大量丙氨酸。突变小鼠的尿丙氨酸对D-氨基酸氧化酶敏感。高效液相色谱显示，约94%的尿丙氨酸具有D-构型。这些结果表明，D-氨基酸氧化酶在正常小鼠中具有分解D-氨基酸的功能。
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