Konno R, Niwa A, Yasumura Y
Department of Microbiology, Dokkyo University School of Medicine, Tochigi, Japan.
Biochem J. 1990 Jun 1;268(2):263-5. doi: 10.1042/bj2680263.
Urine from mutant mice which lack D-amino-acid oxidase contained a large amount of D-alanine. The alanine content was not changed by changes in the dietary composition or by starvation. However, oral administration of an antibiotic, amoxicillin, decreased the urinary alanine to the normal level. These results suggest that the D-alanine is not of dietary origin but of intestinal bacterial origin.
缺乏D-氨基酸氧化酶的突变小鼠尿液中含有大量D-丙氨酸。饮食组成的改变或饥饿状态下，丙氨酸含量并未改变。然而，口服抗生素阿莫西林可使尿丙氨酸降至正常水平。这些结果表明，D-丙氨酸并非来源于饮食，而是来源于肠道细菌。
