• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

硫柳汞和铝对斑马鱼肝脏、肾脏及脑部的毒理学效应（）

Toxicological Effects of Thimerosal and Aluminum in the Liver, Kidney, and Brain of Zebrafish ().

作者信息

Galiciolli Maria Eduarda Andrade, Silva Juliana Ferreira, Prodocimo Maritana Mela, Laureano Henrique Aparecido, Calado Sabrina Loise de Morais, Oliveira Claudia Sirlene, Guiloski Izonete Cristina

机构信息

Instituto de Pesquisa Pelé Pequeno Príncipe, Avenida Silva Jardim, 1632, Água Verde, Curitiba 80250-200, PR, Brazil.

Faculdades Pequeno Príncipe, Curitiba 80230-020, PR, Brazil.

出版信息

Metabolites. 2023 Aug 27;13(9):975. doi: 10.3390/metabo13090975.

DOI:10.3390/metabo13090975
PMID:37755255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10537066/
Abstract

Vaccination programs in the first years of a child's life are effective and extremely important strategies for the successful eradication of diseases. However, as no intervention is without risks, the metal-based components of some vaccines, such as thimerosal (TMS), a preservative composed of ethylmercury, and aluminum (Al), have begun to generate distrust on the part of the population. Therefore, this study evaluated the effects of exposure to thimerosal and aluminum hydroxide (alone or in mixture) on (zebrafish) specimens. The fish were exposed to thimerosal and/or aluminum hydroxide intraperitoneally. The liver, kidney, and brain were removed for a biochemical biomarker analysis, histopathological analysis, and metal quantification. As a result, we observed changes in the activity of the analyzed enzymes (SOD, GST, GPx) in the kidney and brain of the zebrafish, a reduction in GSH levels in all analyzed tissues, and a reduction in MT levels in the kidney and liver as well as in the brain. Changes in AChE enzyme activity were observed. The biochemical results corroborate the changes observed in the lesion index and histomorphology sections. We emphasize the importance of joint research on these compounds to increase the population's safety against their possible toxic effects.

摘要

儿童生命最初几年的疫苗接种计划是成功根除疾病的有效且极其重要的策略。然而，由于没有任何干预是没有风险的，一些疫苗中的金属成分，如硫柳汞（TMS）（一种由乙基汞组成的防腐剂）和铝（Al），已开始引起公众的不信任。因此，本研究评估了暴露于硫柳汞和氢氧化铝（单独或混合）对斑马鱼样本的影响。将鱼通过腹腔注射暴露于硫柳汞和/或氢氧化铝。取出肝脏、肾脏和大脑进行生化生物标志物分析、组织病理学分析和金属定量。结果，我们观察到斑马鱼肾脏和大脑中分析的酶（超氧化物歧化酶、谷胱甘肽S-转移酶、谷胱甘肽过氧化物酶）活性发生变化，所有分析组织中的谷胱甘肽水平降低，肾脏、肝脏以及大脑中的金属硫蛋白水平降低。观察到乙酰胆碱酯酶活性发生变化。生化结果证实了在病变指数和组织形态学切片中观察到的变化。我们强调对这些化合物进行联合研究的重要性，以提高公众对其可能的毒性作用的安全性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/bd1cd387c885/metabolites-13-00975-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/5fd96a0b07ec/metabolites-13-00975-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/a5a9c9098a26/metabolites-13-00975-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/a248464c3878/metabolites-13-00975-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/63a97000e57c/metabolites-13-00975-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/70d719a17670/metabolites-13-00975-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/8a5f267fdd93/metabolites-13-00975-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/db3d318caeef/metabolites-13-00975-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/39e49097da75/metabolites-13-00975-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/cd5156829d08/metabolites-13-00975-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/b3bec45c7320/metabolites-13-00975-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/bd1cd387c885/metabolites-13-00975-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/5fd96a0b07ec/metabolites-13-00975-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/a5a9c9098a26/metabolites-13-00975-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/a248464c3878/metabolites-13-00975-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/63a97000e57c/metabolites-13-00975-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/70d719a17670/metabolites-13-00975-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/8a5f267fdd93/metabolites-13-00975-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/db3d318caeef/metabolites-13-00975-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/39e49097da75/metabolites-13-00975-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/cd5156829d08/metabolites-13-00975-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/b3bec45c7320/metabolites-13-00975-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2956/10537066/bd1cd387c885/metabolites-13-00975-g011.jpg

相似文献

1
Toxicological Effects of Thimerosal and Aluminum in the Liver, Kidney, and Brain of Zebrafish ().硫柳汞和铝对斑马鱼肝脏、肾脏及脑部的毒理学效应（）
Metabolites. 2023 Aug 27;13(9):975. doi: 10.3390/metabo13090975.
2
Does acute exposure to thimerosal, an organic mercury compound, affect the mitochondrial function of an infant model?急性接触硫柳汞（一种有机汞化合物）是否会影响婴儿模型的线粒体功能？
J Trace Elem Med Biol. 2024 May;83:127399. doi: 10.1016/j.jtemb.2024.127399. Epub 2024 Jan 22.
3
Sublethal psychotropic pharmaceutical effects on the model organism Danio rerio: Oxidative stress and metal dishomeostasis.亚致死性精神类药物对模式生物斑马鱼的影响：氧化应激和金属离子稳态失调。
Ecotoxicol Environ Saf. 2019 Apr 30;171:781-789. doi: 10.1016/j.ecoenv.2019.01.041. Epub 2019 Jan 17.
4
Acute selenium selenite exposure effects on oxidative stress biomarkers and essential metals and trace-elements in the model organism zebrafish (Danio rerio).急性亚硒酸钠暴露对模式生物斑马鱼（Danio rerio）氧化应激生物标志物及必需金属和微量元素的影响。
J Trace Elem Med Biol. 2016 Jan;33:68-72. doi: 10.1016/j.jtemb.2015.09.001. Epub 2015 Sep 21.
5
Toxicity assessment of pyriproxyfen in vertebrate model zebrafish embryos (Danio rerio): A multi biomarker study.吡丙醚对脊椎动物模式生物斑马鱼胚胎（Danio rerio）的毒性评估：一项多生物标志物研究。
Aquat Toxicol. 2018 Mar;196:132-145. doi: 10.1016/j.aquatox.2018.01.010. Epub 2018 Jan 12.
6
Effects of sodium dodecylbenzene sulfonate (SDBS), active principle of detergents, on the liver and kidney of zebrafish ().洗涤剂的活性成分十二烷基苯磺酸钠（SDBS）对斑马鱼肝脏和肾脏的影响（）
Int J Environ Health Res. 2024 Jun 20:1-14. doi: 10.1080/09603123.2024.2369221.
7
Assessment of thimerosal effects in sublethal concentrations on zebrafish (Danio rerio) embryos exploring NMR-based metabolomics profile.评估亚致死浓度下硫柳汞对斑马鱼（Danio rerio）胚胎的影响，探索基于 NMR 的代谢组学特征。
Environ Toxicol Pharmacol. 2024 Mar;106:104361. doi: 10.1016/j.etap.2024.104361. Epub 2024 Jan 9.
8
Evaluation of thimerosal removal on immunogenicity of aluminum salts adjuvanted recombinant hepatitis B vaccine.硫柳汞去除对铝盐佐剂重组乙型肝炎疫苗免疫原性的评估
Iran J Pharm Res. 2012 Winter;11(1):39-46.
9
Biochemical response of diverse organs in adult Danio rerio (zebrafish) exposed to sub-lethal concentrations of microcystin-LR and microcystin-RR: a balneation study.暴露于亚致死浓度微囊藻毒素-LR 和微囊藻毒素-RR 下的成年斑马鱼（Danio rerio）不同器官的生化反应：浸浴研究。
Aquat Toxicol. 2012 Mar;109:1-10. doi: 10.1016/j.aquatox.2011.11.009. Epub 2011 Nov 26.
10
Evaluation of the Toxic Effects of Aluminum Hydroxide Nanoparticles as Adjuvants in Vaccinated Neonatal Mice.评价纳米氢氧化铝作为佐剂在接种新生小鼠中的毒副作用。
Arch Razi Inst. 2022 Feb 28;77(1):221-228. doi: 10.22092/ARI.2021.356418.1839. eCollection 2022 Feb.

本文引用的文献

1
Toxicological effects of thimerosal on rat kidney: a histological and biochemical study.硫柳汞对大鼠肾脏的毒理学作用：组织学和生化研究。
Braz J Biol. 2021 Aug 27;83:e242942. doi: 10.1590/1519-6984.242942. eCollection 2021.
2
Dietary exposure to methyl mercury chloride induces alterations in hematology, biochemical parameters, and mRNA expression of antioxidant enzymes and metallothionein in Nile tilapia.膳食暴露于甲基氯化汞会引起尼罗罗非鱼血液学、生化参数以及抗氧化酶和金属硫蛋白的 mRNA 表达的改变。
Environ Sci Pollut Res Int. 2021 Jun;28(24):31391-31402. doi: 10.1007/s11356-021-13014-5. Epub 2021 Feb 19.
3
Sulfhydryl groups as targets of mercury toxicity.
巯基作为汞毒性的靶点。
Coord Chem Rev. 2020 Aug 15;417. doi: 10.1016/j.ccr.2020.213343. Epub 2020 May 7.
4
Neurotoxic effects of combined exposures to aluminum and mercury in early life (infancy).早期生活（婴儿期）中铝和汞联合暴露的神经毒性作用。
Environ Res. 2020 Sep;188:109734. doi: 10.1016/j.envres.2020.109734. Epub 2020 Jun 8.
5
Iron and Manganese Retention of Juvenile Zebrafish (Danio rerio) Exposed to Contaminated Dietary Zooplankton (Daphnia pulex)-a Model Experiment.受污染食物性浮游动物（水蚤）暴露下的幼斑马鱼（斑马鱼属）的铁和锰保留——模型实验。
Biol Trace Elem Res. 2021 Feb;199(2):732-743. doi: 10.1007/s12011-020-02190-z. Epub 2020 May 23.
6
Neurodevelopmental Effects of Mercury.汞对神经发育的影响。
Adv Neurotoxicol. 2018;2:27-86. doi: 10.1016/bs.ant.2018.03.005. Epub 2018 May 24.
7
Acute exposure and chronic retention of aluminum in three vaccine schedules and effects of genetic and environmental variation.三种疫苗接种方案中的急性暴露和慢性蓄积铝，以及遗传和环境变异的影响。
J Trace Elem Med Biol. 2020 Mar;58:126444. doi: 10.1016/j.jtemb.2019.126444. Epub 2019 Dec 5.
8
Methyl and Ethylmercury elicit oxidative stress and unbalance the antioxidant system in Saccharomyces cerevisiae.甲基汞和乙基汞会引发氧化应激，使酿酒酵母中的抗氧化系统失去平衡。
Chem Biol Interact. 2020 Jan 5;315:108867. doi: 10.1016/j.cbi.2019.108867. Epub 2019 Oct 28.
9
Immune-mediated adverse reactions to vaccines.疫苗免疫介导的不良反应。
Br J Clin Pharmacol. 2019 Dec;85(12):2694-2706. doi: 10.1111/bcp.14112. Epub 2019 Nov 5.
10
Methylmercury's chemistry: From the environment to the mammalian brain.甲基汞的化学性质：从环境到哺乳动物大脑。
Biochim Biophys Acta Gen Subj. 2019 Dec;1863(12):129284. doi: 10.1016/j.bbagen.2019.01.006. Epub 2019 Jan 17.