食物过敏的口服和舌下免疫疗法。
Oral and sublingual immunotherapy for food allergy.
作者信息
Le Uyenphuong H, Burks A Wesley
机构信息
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill NC 260 MacNider Hall, CB 7220, Chapel Hill, NC 27599-7220 USA.
出版信息
World Allergy Organ J. 2014 Dec 8;7(1):35. doi: 10.1186/1939-4551-7-35. eCollection 2014.
Abstract
IgE-mediated food allergy is a potentially life-threatening allergic disease with an increase in prevalence in developed countries over the past 15 years. Currently, there are no approved forms of therapy and the standard of care is dietary restriction and ready access to emergency medications, such as self-injectable epinephrine and antihistamines. Allergen-specific modalities of treatment currently being studied include oral immunotherapy (OIT) and sublingual immunotherapy (SLIT). Both forms demonstrate the ability to desensitize patients to a variety of specific food allergens and show great promise. However, more research is needed to evaluate the safety and efficacy of OIT and SLIT prior to routine use in clinical practice.
摘要
IgE介导的食物过敏是一种潜在的危及生命的过敏性疾病，在过去15年里，其在发达国家的患病率有所上升。目前，尚无获批的治疗方式，护理标准是饮食限制以及随时可获取紧急药物，如自动注射肾上腺素和抗组胺药。目前正在研究的特异性变应原治疗方式包括口服免疫疗法（OIT）和舌下免疫疗法（SLIT）。这两种方式均显示出使患者对多种特定食物变应原脱敏的能力，前景广阔。然而，在临床实践中常规使用之前，还需要更多研究来评估OIT和SLIT的安全性和有效性。
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