Chervenkoff Jordan V, Hawkes Elizabeth, Ortiz Gabriela, Horney Deborah, Nanavaty Mayank A
Sussex Eye Hospital, Brighton & Sussex University Hospitals NHS Trust, Eastern Road, Brighton, BN2 5BF UK.
Eye Vis (Lond). 2017 Aug 14;4:19. doi: 10.1186/s40662-017-0084-8. eCollection 2017.
To investigate the effect of eye rubbing on keratometry (K), aberrometry, tear film break-up-time (TFBUT) and anterior chamber depth (ACD).
Volunteers without any corneal pathology or dry eyes were randomised to rubbing in one eye and the fellow-eye was control. Eye rubbing was performed for 2 min. Primary outcomes studied were anterior and posterior K changes. Secondary outcomes were changes in TFBUT, axial length (AL) & ACD, K changes in various zones, asphericity and aberrometry. Pre and post rubbing K, aberrometry, ACD and TFBUT were assessed in a predetermined sequence. The relationship of the above parameters to axial length (AL) was also assessed. Astigmatism was analysed using vector analysis.
Pre versus post rubbing, anterior flatter K further flattened (42.51 ± 1.52 D vs. 42.36 ± 1.53 D, = 0.003) and the changes to J0 vector in central cornea (-0.16 ± 0.26 D vs. -0.27 ± 0.33 D, = 0.038) suggested change to against-the-rule (ATR) astigmatism. There was significant change in Z polynomial following rubbing. We found a positive correlation between axial length and change in posterior K ( = 0.335, = 0.020). The TFBUT reduced following eye rubbing (15.3 s vs. 13.9 s, = 0.0001). There was a positive correlation between AL and increase in ACD post rubbing ( = 0.300, = 0.038). There was a positive correlation between ACD and change in mean posterior K ( = 0.305, = 0.035).
In healthy eyes, following eye rubbing, there is a significant change in TFBUT and central anterior K changes towards ATR astigmatism. Longer eyes had more changes in posterior K and ACD. Whereas, eyes with deeper ACD showed more steepness of posterior K.
ClinicalTrials.gov ID: NCT02131740.
研究揉眼对角膜曲率计测量值（K值）、像差、泪膜破裂时间（TFBUT）及前房深度（ACD）的影响。
将无任何角膜病变或干眼的志愿者随机分为一组，一组眼揉擦2分钟，另一眼作为对照。主要研究指标为前后角膜曲率变化。次要指标为TFBUT、眼轴长度（AL）及ACD的变化、不同区域的K值变化、非球面性及像差。按照预定顺序评估揉眼前后的K值、像差、ACD及TFBUT。还评估了上述参数与眼轴长度（AL）的关系。采用矢量分析分析散光。
揉眼前后，前表面较平的K值进一步变平（42.51±1.52D对42.36±1.53D，P=0.003），角膜中央J0矢量的变化（-0.16±0.26D对-0.27±0.33D，P=0.038）提示逆规（ATR）散光的改变。揉眼后Z多项式有显著变化。我们发现眼轴长度与后表面K值变化之间存在正相关（r=0.335，P=0.020）。揉眼后TFBUT缩短（15.3秒对13.9秒，P=0.0001）。AL与揉眼后ACD增加之间存在正相关（r=0.300，P=0.038）。ACD与后表面平均K值变化之间存在正相关（r=0.305，P=0.035）。
在健康眼中，揉眼后TFBUT有显著变化，中央前表面K值向ATR散光方向改变。眼轴较长者后表面K值和ACD变化更大。而ACD较深的眼后表面K值更陡峭。
ClinicalTrials.gov标识符：NCT02131740。
