使用头皮脑电图和先进人工智能技术的癫痫发作自动检测
Automatic epileptic seizure detection using scalp EEG and advanced artificial intelligence techniques.
作者信息
Fergus Paul, Hignett David, Hussain Abir, Al-Jumeily Dhiya, Abdel-Aziz Khaled
机构信息
Applied Computing Research Group, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK.
The Walton Centre NHS Foundation Trust, Lower Lane, Fazakerley, Liverpool L9 7LJ, UK.
出版信息
Biomed Res Int. 2015;2015:986736. doi: 10.1155/2015/986736. Epub 2015 Jan 29.
The epilepsies are a heterogeneous group of neurological disorders and syndromes characterised by recurrent, involuntary, paroxysmal seizure activity, which is often associated with a clinicoelectrical correlate on the electroencephalogram. The diagnosis of epilepsy is usually made by a neurologist but can be difficult to be made in the early stages. Supporting paraclinical evidence obtained from magnetic resonance imaging and electroencephalography may enable clinicians to make a diagnosis of epilepsy and investigate treatment earlier. However, electroencephalogram capture and interpretation are time consuming and can be expensive due to the need for trained specialists to perform the interpretation. Automated detection of correlates of seizure activity may be a solution. In this paper, we present a supervised machine learning approach that classifies seizure and nonseizure records using an open dataset containing 342 records. Our results show an improvement on existing studies by as much as 10% in most cases with a sensitivity of 93%, specificity of 94%, and area under the curve of 98% with a 6% global error using a k-class nearest neighbour classifier. We propose that such an approach could have clinical applications in the investigation of patients with suspected seizure disorders.
癫痫是一组异质性的神经系统疾病和综合征,其特征为反复出现的、非自愿的、阵发性发作活动,通常与脑电图上的临床电相关性有关。癫痫的诊断通常由神经科医生做出,但在早期阶段可能难以诊断。从磁共振成像和脑电图获得的辅助临床证据可能使临床医生能够更早地诊断癫痫并研究治疗方法。然而,脑电图的捕捉和解读耗时且可能昂贵,因为需要训练有素的专家进行解读。癫痫发作活动相关性的自动检测可能是一种解决方案。在本文中,我们提出了一种监督式机器学习方法,该方法使用包含342条记录的开放数据集对癫痫发作和非癫痫发作记录进行分类。我们的结果表明,在大多数情况下,与现有研究相比有高达10%的改进,使用k类最近邻分类器时,灵敏度为93%,特异性为94%,曲线下面积为98%,全局误差为6%。我们认为这种方法在疑似癫痫发作障碍患者的调查中可能具有临床应用价值。