西红花及其成分对记忆的影响：基础研究与临床应用。
The Effect of Crocus sativus L. and Its Constituents on Memory: Basic Studies and Clinical Applications.
机构信息
Department of Pharmacology, School of Medicine, Faculty of Health Sciences, University of Thessaly, Panepistimiou 3, Biopolis, 41500 Larissa, Greece.
出版信息
Evid Based Complement Alternat Med. 2015;2015:926284. doi: 10.1155/2015/926284. Epub 2015 Feb 1.
Abstract
Memory-related disorders are a common public health issue. Memory impairment is frequent in degenerative diseases (such as Alzheimer's disease and Parkinson disease), cerebral injuries, and schizophrenia. The dried stigma of the plant Crocus sativus L. (C. sativus), commonly known as saffron, is used in folk medicine for various purposes. Several lines of evidence suggest that C. sativus and its constituents are implicated in cognition. Here we critically review advances in research of these emerging molecular targets for the treatment of memory disorders, and discuss their advantages over currently used cognitive enhancers as well remaining challenges. Current analysis has shown that C. sativus and its components might be a promising target for cognition impairments.
摘要
记忆相关障碍是一个常见的公共卫生问题。记忆损伤在退行性疾病（如阿尔茨海默病和帕金森病）、脑损伤和精神分裂症中很常见。植物藏红花（Crocus sativus L.）的干燥柱头（通常称为藏红花）在民间医学中用于各种用途。有几条证据表明，藏红花及其成分与认知有关。在这里，我们批判性地回顾了这些新兴分子靶点治疗记忆障碍的研究进展，并讨论了它们相对于目前使用的认知增强剂的优势以及仍然存在的挑战。目前的分析表明，藏红花及其成分可能是认知障碍的一个有前途的靶点。
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Hum Psychopharmacol. 2014 Jul;29(4):351-9. doi: 10.1002/hup.2412.
2
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Food Chem Toxicol. 2014 Feb;64:65-80. doi: 10.1016/j.fct.2013.11.016. Epub 2013 Nov 22.
3
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Psychopharmacology (Berl). 2014 Feb;231(4):717-26. doi: 10.1007/s00213-013-3293-4. Epub 2013 Oct 6.
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