亨廷顿蛋白促进选择性自噬。
Huntingtin facilitates selective autophagy.
机构信息
Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel.
出版信息
Nat Cell Biol. 2015 Mar;17(3):214-5. doi: 10.1038/ncb3125.
DOI:10.1038/ncb3125
PMID:25720962
Abstract
Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the induction of autophagy and the selective recruitment of cargo into autophagosomes.
摘要
选择性自噬对于在不同生长条件下维持细胞内稳态至关重要。现已表明，亨廷顿病相关突变体的亨廷顿蛋白（huntingtin）作为一种支架蛋白，可将自噬的诱导与货物的选择性募集到自噬体结合起来。
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