5-羟色胺可能是虹鳟鱼（萨氏虹鳟）胃纵肌中非胆碱能兴奋性神经的一种神经递质。
5-Hydroxytryptamine is a possible neurotransmitter of the non-cholinergic excitatory nerves in the longitudinal muscle of rainbow trout stomach (Salmo gairdneri).
作者信息
Kitazawa T
机构信息
Department of Veterinary Pharmacology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan.
出版信息
Br J Pharmacol. 1989 Nov;98(3):781-90. doi: 10.1111/j.1476-5381.1989.tb14606.x.
Abstract
- The neurotransmitter of the non-cholinergic excitatory nerves in the rainbow trout stomach was identified on the basis of the pharmacological properties of the contractile responses to transmural stimulation (TMS) and nicotine. 2. TMS caused tetrodotoxin-sensitive contractions of rainbow trout stomach strips in a frequency-dependent manner (0.5-50 Hz). Atropine (1 microM) significantly decreased the contractile response to low-frequency stimulation (0.5-2 Hz), but did not affect that to high-frequency stimulation (3-20 Hz). 3. The atropine-resistant contractile response to TMS (20 Hz) was unaffected by hexamethonium (100 microM), phentolamine (5.4 microM), pyrilamine (1 microM), naloxone (1 microM) or substance P-induced desensitization. 4. 5-Hydroxytryptamine (5-HT, 3 nM-3 microM) caused atropine-resistant contractions in a concentration-dependent manner. In the presence of atropine, methysergide (1 microM) decreased the contractile responses to TMS and 5-HT. 5. Nicotine (3 microM-500 microM) induced atropine-resistant contractions that were completely abolished by tetrodotoxin or hexamethonium. Also methysergide inhibited the contractile responses to nicotine. 6. An acid extract of rainbow trout stomach exhibited atropine-resistant contractions that were decreased by methysergide, in both rainbow trout stomach and guinea-pig ileum longitudinal smooth muscle preparations. 7. The present results indicate that, in longitudinal muscle strips of the rainbow trout stomach, 5-HT is one of the mediators (neurotransmitters) of the non-cholinergic excitatory contractions induced by TMS and nicotine.
摘要
- 根据对跨壁刺激（TMS）和尼古丁收缩反应的药理学特性，确定了虹鳟鱼胃中非胆碱能兴奋性神经的神经递质。2. TMS以频率依赖性方式（0.5 - 50Hz）引起虹鳟鱼胃条的河豚毒素敏感收缩。阿托品（1μM）显著降低对低频刺激（0.5 - 2Hz）的收缩反应，但不影响对高频刺激（3 - 20Hz）的收缩反应。3. 对TMS（20Hz）的阿托品抵抗性收缩反应不受六甲铵（100μM）、酚妥拉明（5.4μM）、吡苄明（1μM）、纳洛酮（1μM）或P物质诱导的脱敏作用影响。4. 5-羟色胺（5-HT，3nM - 3μM）以浓度依赖性方式引起阿托品抵抗性收缩。在存在阿托品的情况下，麦角新碱（1μM）降低对TMS和5-HT的收缩反应。5. 尼古丁（3μM - 500μM）诱导的阿托品抵抗性收缩被河豚毒素或六甲铵完全消除。麦角新碱也抑制对尼古丁的收缩反应。6. 虹鳟鱼胃的酸提取物在虹鳟鱼胃和豚鼠回肠纵行平滑肌制备物中均表现出阿托品抵抗性收缩，且被麦角新碱降低。7. 目前的结果表明，在虹鳟鱼胃的纵行肌条中，5-HT是由TMS和尼古丁诱导的非胆碱能兴奋性收缩的介质（神经递质）之一。
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