Wong T W, Chan Y C, Joo Y G, Lee H W, Lee P W, Yanagihara R
Department of Community, National University of Singapore.
Trans R Soc Trop Med Hyg. 1989 Mar-Apr;83(2):248-51. doi: 10.1016/0035-9203(89)90666-4.
To determine the extent of hantavirus infection in Singapore, serological studies using the indirect immunofluorescent antibody (IFA) test were conducted on commensal rodents and on human patients in 4 diagnostic groups. Virus isolation using a Vero E6 cell line was performed on hantaviral antigen-positive rodent lung tissue. Of 142 rodents and 3 insectivores studied, 37 (26%) were seropositive for IFA. Rattus norvegicus was the predominant species captured, with the highest species-specific seropositive rate of 32% (36 of 113). A hantavirus strain, R36, was isolated from one R. norvegicus. Seropositive rates for human patients were: 8% respectively for dengue haemorrhagic fever suspects and for non-A non-B hepatitis patients, 3% for leptospirosis suspects and 2% for acute nephritis patients. 2 patients had marked liver dysfunction but mild renal involvement. This hepatitis-like manifestation appears to be a clinical variant of hantavirus infection.
为确定新加坡汉坦病毒感染的程度，对4个诊断组的野生啮齿动物和人类患者进行了采用间接免疫荧光抗体（IFA）检测的血清学研究。对汉坦病毒抗原阳性的啮齿动物肺组织进行了使用Vero E6细胞系的病毒分离。在研究的142只啮齿动物和3只食虫动物中，37只（26%）IFA血清学阳性。褐家鼠是捕获的主要物种，其物种特异性血清学阳性率最高，为32%（113只中的36只）。从一只褐家鼠中分离出一株汉坦病毒毒株R36。人类患者的血清学阳性率分别为：登革出血热疑似患者和非甲非乙型肝炎患者均为8%，钩端螺旋体病疑似患者为3%，急性肾炎患者为2%。2名患者有明显肝功能障碍但肾脏受累较轻。这种肝炎样表现似乎是汉坦病毒感染的一种临床变异型。
