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High-level fluoroquinolone resistant Salmonella enterica serovar Kentucky ST198 epidemic clone with IncA/C conjugative plasmid carrying bla(CTX-M-25) gene.携带bla(CTX-M-25)基因的IncA/C接合质粒的高水平氟喹诺酮耐药肠炎沙门氏菌肯塔基血清型ST198流行克隆
Vet Microbiol. 2015 Jan 30;175(1):85-91. doi: 10.1016/j.vetmic.2014.10.014. Epub 2014 Oct 24.
2
Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding.产碳青霉烯酶肺炎克雷伯菌：分子与基因解码
Trends Microbiol. 2014 Dec;22(12):686-96. doi: 10.1016/j.tim.2014.09.003. Epub 2014 Oct 7.
3
Single-molecule sequencing to track plasmid diversity of hospital-associated carbapenemase-producing Enterobacteriaceae.单分子测序追踪医院相关产碳青霉烯酶肠杆菌科细菌的质粒多样性
Sci Transl Med. 2014 Sep 17;6(254):254ra126. doi: 10.1126/scitranslmed.3009845.
4
Comparative genomic analysis of KPC-encoding pKpQIL-like plasmids and their distribution in New Jersey and New York Hospitals.编码KPC的pKpQIL样质粒的比较基因组分析及其在新泽西州和纽约医院的分布。
Antimicrob Agents Chemother. 2014 May;58(5):2871-7. doi: 10.1128/AAC.00120-14. Epub 2014 Mar 10.
5
Molecular survey of the dissemination of two blaKPC-harboring IncFIA plasmids in New Jersey and New York hospitals.新泽西州和纽约市医院中携带blaKPC的两种IncFIA质粒传播的分子调查。
Antimicrob Agents Chemother. 2014;58(4):2289-94. doi: 10.1128/AAC.02749-13. Epub 2014 Feb 3.
6
Complete sequence of a KPC-producing IncN multidrug-resistant plasmid from an epidemic Escherichia coli sequence type 131 strain in China.来自中国一株流行的大肠杆菌序列型131菌株的产KPC的IncN多药耐药质粒的完整序列。
Antimicrob Agents Chemother. 2014;58(4):2422-5. doi: 10.1128/AAC.02587-13. Epub 2014 Jan 6.
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Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.全球扩展型碳青霉烯酶肺炎克雷伯菌的临床流行病学。
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A cointegrate-like plasmid that facilitates dissemination by conjugation of the extended-spectrum β-lactamase CTX-M-17.一种促进超广谱β-内酰胺酶CTX-M-17通过接合作用进行传播的类共整合质粒。
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Complete nucleotide sequences of blaKPC-4- and blaKPC-5-harboring IncN and IncX plasmids from Klebsiella pneumoniae strains isolated in New Jersey.新泽西分离的肺炎克雷伯菌中携带 blaKPC-4 和 blaKPC-5 的 IncN 和 IncX 质粒的完整核苷酸序列。
Antimicrob Agents Chemother. 2013 Jan;57(1):269-76. doi: 10.1128/AAC.01648-12. Epub 2012 Oct 31.
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Antimicrobial treatment and containment measures for an extremely drug-resistant Klebsiella pneumoniae ST101 isolate carrying pKPN101-IT, a novel fully sequenced bla(KPC-2) plasmid.携带 pKPN101-IT 的耐多药肺炎克雷伯菌 ST101 株的抗菌治疗和控制措施，该质粒为新型完全测序 bla(KPC-2) 质粒。
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从大肠杆菌中分离出的携带bla(KPC)的共整合质粒的完整序列。

Complete sequence of a bla(KPC)-harboring cointegrate plasmid isolated from Escherichia coli.

作者信息

Chavda Kalyan D, Chen Liang, Jacobs Michael R, Rojtman Albert D, Bonomo Robert A, Kreiswirth Barry N

机构信息

Public Health Research Institute Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.

Department of Pathology, University Hospitals Case Medical Center, Cleveland, Ohio, USA.

出版信息

Antimicrob Agents Chemother. 2015 May;59(5):2956-9. doi: 10.1128/AAC.00041-15. Epub 2015 Mar 9.

DOI:10.1128/AAC.00041-15
PMID:25753632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4394832/
Abstract

Horizontal transfer of bla(KPC)-harboring plasmids contributes significantly to the inter- and intraspecies spread of Klebsiella pneumoniae carbapenemase (KPC). Here we report the complete nucleotide sequence of a bla(KPC)-harboring IncFIA plasmid, pBK32533, from Escherichia coli. pBK32533 is a cointegrate plasmid comprising of a 72-kb sequence identical to that of the nonconjugative pBK30661 plasmid plus an additional 170-kb element that harbors the genes for plasmid transfer. pBK32533 demonstrates how bla(KPC) can be spread from a nonconjugative plasmid through cointegration.

摘要

携带bla(KPC)的质粒的水平转移对肺炎克雷伯菌碳青霉烯酶（KPC）在种间和种内的传播有显著贡献。在此，我们报告了来自大肠杆菌的携带bla(KPC)的IncFIA质粒pBK32533的完整核苷酸序列。pBK32533是一个共整合质粒，由一段与非接合性质粒pBK30661相同的72 kb序列以及一个额外的170 kb元件组成，该元件含有质粒转移基因。pBK32533展示了bla(KPC)如何通过共整合从非接合性质粒传播。