Tatsugami Fuminari, Higaki Toru, Fukumoto Wataru, Kaichi Yoko, Fujioka Chikako, Kiguchi Masao, Yamamoto Hideya, Kihara Yasuki, Awai Kazuo
Department of Diagnostic Radiology, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan,
Int J Cardiovasc Imaging. 2015 Jun;31(5):1045-52. doi: 10.1007/s10554-015-0637-7. Epub 2015 Mar 10.
To assess the possibility of reducing the radiation dose for coronary artery calcium (CAC) scoring by using adaptive iterative dose reduction 3D (AIDR 3D) on a 320-detector CT scanner. Fifty-four patients underwent routine- and low-dose CT for CAC scoring. Low-dose CT was performed at one-third of the tube current used for routine-dose CT. Routine-dose CT was reconstructed with filtered back projection (FBP) and low-dose CT was reconstructed with AIDR 3D. We compared the calculated Agatston-, volume-, and mass scores of these images. The overall percentage difference in the Agatston-, volume-, and mass scores between routine- and low-dose CT studies was 15.9, 11.6, and 12.6%, respectively. There were no significant differences in the routine- and low-dose CT studies irrespective of the scoring algorithms applied. The CAC measurements of both imaging modalities were highly correlated with respect to the Agatston- (r = 0.996), volume- (r = 0.996), and mass score (r = 0.997; p < 0.001, all); the Bland-Altman limits of agreement scores were -37.4 to 51.4, -31.2 to 36.4 and -30.3 to 40.9%, respectively, suggesting that AIDR 3D was a good alternative for FBP. The mean effective radiation dose for routine- and low-dose CT was 2.2 and 0.7 mSv, respectively. The use of AIDR 3D made it possible to reduce the radiation dose by 67% for CAC scoring without impairing the quantification of coronary calcification.
为评估在320排CT扫描仪上使用自适应迭代剂量降低3D（AIDR 3D）技术降低冠状动脉钙化（CAC）评分辐射剂量的可能性。54例患者接受了用于CAC评分的常规剂量和低剂量CT检查。低剂量CT扫描时管电流为常规剂量CT的三分之一。常规剂量CT采用滤波反投影（FBP）重建，低剂量CT采用AIDR 3D重建。我们比较了这些图像计算得出的阿加斯顿、体积和质量评分。常规剂量和低剂量CT研究之间阿加斯顿、体积和质量评分的总体百分比差异分别为15.9%、11.6%和12.6%。无论应用何种评分算法，常规剂量和低剂量CT研究之间均无显著差异。两种成像方式的CAC测量在阿加斯顿评分（r = 0.996）、体积评分（r = 0.996）和质量评分（r = 0.997；p < 0.001，均如此）方面高度相关；布兰德-奥特曼一致性界限评分分别为-37.4%至51.4%、-31.2%至36.4%和-30.3%至40.9%，表明AIDR 3D是FBP的良好替代方案。常规剂量和低剂量CT的平均有效辐射剂量分别为2.2和0.7 mSv。使用AIDR 3D可在不影响冠状动脉钙化定量的情况下将CAC评分的辐射剂量降低67%。
