小鼠Hox-4.1基因的染色体定位

Chromosome assignment of the murine Hox-4.1 gene.

作者信息

Pravtcheva D, Newman M, Hunihan L, Lonai P, Ruddle F H

机构信息

Department of Biology, Yale University, New Haven, Connecticut 06511.

出版信息

Genomics. 1989 Oct;5(3):541-5. doi: 10.1016/0888-7543(89)90021-9.

DOI:10.1016/0888-7543(89)90021-9

PMID:2575585

Abstract

The murine homebox gene 4.1 was assigned to chromosome 2 by Southern analysis of somatic cell hybrids and by in situ hybridization. This assignment and the report of Featherstone et al. (M. S. Featherstone, A. Baron, S. J. Gaunt, M. G. Mattei, and D. Duboule, 1988, Proc. Natl. Acad. Sci. USA, 85, 4760-4764) indicate that a fourth group of homeobox genes is located on chromosome 2 in the mouse (in addition to the homeobox gene clusters on chromosomes 6, 11, and 15).

摘要

通过对体细胞杂种的Southern分析和原位杂交，将小鼠同源框基因4.1定位于2号染色体。这一定位以及Featherstone等人的报告（M. S. Featherstone、A. Baron、S. J. Gaunt、M. G. Mattei和D. Duboule，1988年，《美国国家科学院院刊》，85卷，4760 - 4764页）表明，第四组同源框基因位于小鼠的2号染色体上（除了位于6号、11号和15号染色体上的同源框基因簇之外）。