Cornil J, Guérinot A, Cossy J
Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), UMR 8231, ESPCI ParisTech/CNRS/PSL Research University, 10, rue Vauquelin, 75231 Paris Cedex, France.
Org Biomol Chem. 2015 Apr 14;13(14):4129-42. doi: 10.1039/c5ob00154d. Epub 2015 Mar 11.
A myriad of biologically active products incorporates polyenic frameworks. Among the syntheses developed to access these moieties, metal-catalyzed cross-couplings emerged as reactions of choice especially due to their high stereoselectivity. Particularly, the use of bifunctionalized compounds (linchpin reagents) allows a fast, modular and efficient access to polyenic chains. In this review, we will focus on the preparation of bifunctionalized dienes and on their utilization in the synthesis of polyenes.
众多生物活性产物都包含多烯骨架。在为获取这些部分而开发的合成方法中，金属催化的交叉偶联反应成为了首选反应，特别是因其具有高立体选择性。尤其值得一提的是，使用双官能化化合物（关键试剂）能够快速、模块化且高效地构建多烯链。在本综述中，我们将重点关注双官能化二烯的制备及其在多烯合成中的应用。
