Alicandri-Ciufelli M, Piccinini A, Grammatica A, Molteni G, Spaggiari A, DI Matteo S, Tassi S, Ghidini A, Izzo L, Gioacchini F M, Marchioni D, DI Saverio S, Presutti L
Otolaryngology Department, University Hospital of Modena, Italy;
Plastic Surgery Department, University Hospital of Modena, Italy;
Acta Otorhinolaryngol Ital. 2014 Dec;34(6):406-11.
The aim of our study was to compare, in terms of aesthetic results, the use of synthetic glue to intradermal absorbable sutures in postthyroidectomy and parathyroidectomy wound closure in a single blinded, randomised, per protocol equivalence study. From September 2008 to May 2010, patients undergoing thyroid or parathyroid surgery (with an external approach) at the Otolaryngology Department of the University Hospital of Modena were assessed for eligibility. In total, 42 patients who had had synthetic glue application on surgical incisions (A) and 47 patients who had subcuticular sutures on their surgical incisions (B) were enrolled. The mean of the endpoint (based on the Wound Registry Scale) of group A at 10 days was 1.4, while that in group B (based on the Stony Brook Scar Evaluation Scale) was 2.9. Statistically significant (p = 0.002) and clinically significant (difference of the means = 1.5) differences in the aesthetic results were found between groups A and B at 10 days, with better results in group B. On the other hand, at 3 months, the mean of the endpoint in group A was 3.1 while that in group B was 2.8; no statistically significant (p = 0.62) or clinically significant (difference in means = 0.3) differences were found between groups A and B. In conclusion, synthetic glue differs from subcuticular suture in post-thyroidectomy or post-parathyroidectomy incision for early aesthetic results, with better outcomes for subcuticular sutures. At 3 months, there were no differences in aesthetic outcomes between groups. Moreover, sex, incision length, age, cold/hot blade and correspondence of the incision with a wrinkle in the skin did not seem to influence aesthetic outcomes with this type of incision.
在一项单盲、随机、按方案等效性研究中，我们的研究目的是比较在甲状腺切除术后和甲状旁腺切除术后伤口闭合中，使用合成胶水与皮内可吸收缝线在美学效果方面的差异。从2008年9月至2010年5月，对摩德纳大学医院耳鼻喉科接受甲状腺或甲状旁腺手术（采用外部入路）的患者进行资格评估。总共招募了42例手术切口使用合成胶水的患者（A组）和47例手术切口采用皮下缝合的患者（B组）。A组在10天时终点指标（基于伤口登记量表）的平均值为1.4，而B组（基于石溪瘢痕评估量表）为2.9。在10天时，A组和B组在美学效果上存在统计学显著差异（p = 0.002）和临床显著差异（均值差异 = 1.5），B组效果更好。另一方面，在3个月时，A组终点指标的平均值为3.1，B组为2.8；A组和B组之间未发现统计学显著差异（p = 0.62）或临床显著差异（均值差异 = 0.3）。总之，在甲状腺切除术后或甲状旁腺切除术后切口的早期美学效果方面，合成胶水与皮下缝合不同，皮下缝合效果更好。在3个月时，两组之间的美学结果没有差异。此外，性别、切口长度、年龄、冷/热刀以及切口与皮肤皱纹的对应情况似乎都不会影响这种类型切口的美学结果。
