Andersen Per Normann, Skogli Erik Winther, Hovik Kjell Tore, Egeland Jens, Øie Merete
Division Mental Health Care, Innlandet Hospital Trust, Anders Sandvigsgate 17, 2629, Lillehammer, Norway,
J Autism Dev Disord. 2015 Aug;45(8):2497-507. doi: 10.1007/s10803-015-2415-8.
This study investigated the course of and association among changes in autism symptoms, depression symptoms and executive functions (EF) in children with high-functioning autism (HFA). Thirty-four children with HFA and 45 typically developing children (age 9-16) were assessed at baseline and after 2 years. Children with HFA had impaired scores on all measures at both time points. According to parent reports, depressive symptoms decreased over time, while EF improved and autism symptoms were stable. Children's reports did not reveal less depressive symptoms over time. A positive association was found only between changes in autism symptoms and changes in symptoms of depression. A possible implication is that interventions aimed at either autism symptoms or symptoms of depression may improve the other.
本研究调查了高功能自闭症（HFA）儿童的自闭症症状、抑郁症状和执行功能（EF）变化的过程及相互关系。对34名HFA儿童和45名发育正常的儿童（9 - 16岁）在基线时和2年后进行了评估。HFA儿童在两个时间点的所有测量指标上得分均受损。根据家长报告，抑郁症状随时间减少，而执行功能有所改善，自闭症症状保持稳定。儿童自身报告未显示抑郁症状随时间减少。仅在自闭症症状变化与抑郁症状变化之间发现了正相关。一个可能的启示是，针对自闭症症状或抑郁症状的干预措施可能会改善另一种症状。
