Ianiro Giovanni, Delogu Roberto, Baba Marycelin, Oderinde Bamidele S, Dawurung Joshua, Ruggeri Franco Maria, Fiore Lucia
Istituto Superiore di Sanità, V.le Regina Elena, 299, 00161, Rome, Italy.
Arch Virol. 2015 Jun;160(6):1511-7. doi: 10.1007/s00705-015-2389-z. Epub 2015 Mar 14.
Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in children worldwide and cause up to 455,000 deaths annually, mostly in developing countries. During 2013, 66 RVAs from children with AGE admitted to four Nigerian hospitals were investigated. The G3P[6], G1P[8] and G2P[4] genotypes predominated. The VP7 and/or VP4 genes of 18 G3P[6]/[8]/[4], six G2P[4], three G12P[8]/[4], and two G1P[8] RVA strains were sequenced. The G3P[6] strains belonged to lineage G3-III and were different from G3 strains widespread in Asia. Phylogenetic analysis revealed substantial sequence conservation, suggesting continuing evolution and genomic reassortment but no zoonotic RVA transmission from animals.
A组轮状病毒（RVA）是全球儿童急性胃肠炎（AGE）的主要病因，每年导致多达45.5万人死亡，其中大多数发生在发展中国家。2013年期间，对尼日利亚四家医院收治的66例患急性胃肠炎儿童的RVA进行了调查。G3P[6]、G1P[8]和G2P[4]基因型占主导地位。对18株G3P[6]/[8]/[4]、6株G2P[4]、3株G12P[8]/[4]和2株G1P[8] RVA毒株的VP7和/或VP4基因进行了测序。G3P[6]毒株属于G3-III谱系，与在亚洲广泛传播的G3毒株不同。系统发育分析显示出大量的序列保守性，表明RVA在持续进化和进行基因组重配，但没有动物源性RVA传播。
