阿利西亚醇 A-E：从墨西哥丁香 Dysoxylum alliaceum (Blume) Blume ex A.Juss. 的茎皮中分离得到的五个新的墨西哥醇类化合物。
Alliaxylines A-E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss.
机构信息
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia.
Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia.
出版信息
J Nat Med. 2024 Jun;78(3):558-567. doi: 10.1007/s11418-024-01794-2. Epub 2024 Mar 22.
A total of five new mexicanolides (1-5), namely alliaxylines A-E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI-MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound 2 was the most potent against the two tested cells, with IC values of 34.95 ± 0.21 and 44.39 ± 1.03 µM.
从Dysoxylum alliaceum (Blume) Blume ex. A.Juss.（芸香科）中分离鉴定出 5 个新的墨西哥醇类化合物（1-5），即 Alliaxylines A-E，以及 2 个已知的柠檬苦素类化合物 6 和 7。这些化合物的结构基于广泛的光谱分析，包括 HR-ESI-MS、UV、IR、1D 和 2D NMR 以及 DP4 + 算法的理论模拟进行阐明。因此，本研究旨在检测这些化合物对 MCF-7 和 A549 细胞系的细胞毒性活性。结果表明，化合物 2 对两种测试细胞的抑制活性最强，IC 值分别为 34.95 ± 0.21 和 44.39 ± 1.03 μM。
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