Bm65的过表达与紫外线灭活敏感性降低相关。
Overexpression of Bm65 correlates with reduced susceptibility to inactivation by UV light.
作者信息
Tang Qi, Hu Zhaoyang, Yang Yanhua, Wu Huiling, Qiu Lipeng, Chen Keping, Li Guohui
机构信息
Institute of Life Sciences, Jiangsu University, 301# Xuefu Road, Zhenjiang 212013, China.
Institute of Life Sciences, Jiangsu University, 301# Xuefu Road, Zhenjiang 212013, China.
出版信息
J Invertebr Pathol. 2015 May;127:87-92. doi: 10.1016/j.jip.2015.03.003. Epub 2015 Mar 16.
Ultraviolet (UV) light is one of the factors that causes baculovirus inactivation. However, little is known about the response of baculoviruses to UV light. In the present study, Bombyx mori nucleopolyhedrovirus (BmNPV) orf 65 (Bm65), the homolog of Autographa californica nucleopolyhedrovirus orf 79 (Ac79), a predicted endonuclease, was analyzed. Preliminary results indicated that Bm65 mainly accumulated within the nucleus and could improve the survival rate of Escherichia coli (E. coli) and BmNPV BVs after UV radiation, suggesting that Bm65 was involved in the repair of UV-induced DNA damage.
紫外线（UV）是导致杆状病毒失活的因素之一。然而，关于杆状病毒对紫外线的反应知之甚少。在本研究中，对家蚕核型多角体病毒（BmNPV）的orf 65（Bm65）进行了分析，它是苜蓿银纹夜蛾核型多角体病毒orf 79（Ac79）的同源物，Ac79是一种预测的核酸内切酶。初步结果表明，Bm65主要在细胞核内积累，并且在紫外线照射后可以提高大肠杆菌（E. coli）和BmNPV芽生型病毒（BVs）的存活率，这表明Bm65参与了紫外线诱导的DNA损伤修复。
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