Alaeddini M, Etemad-Moghadam S, Baghaii F
Dental Research Centre, Faculty of Dentistry, Medical Sciences/University of Tehran, Tehran, Iran.
Histopathology. 2008 Feb;52(3):299-304. doi: 10.1111/j.1365-2559.2007.02948.x.
Calretinin, a calcium-binding protein, is expressed primarily in certain subtypes of neurons. It has also been reported to be present in mesotheliomas and other tumours. The aim was to determine the expression of calretinin in selected odontogenic neoplasms.
Immunohistochemistry for calretinin was performed on 55 odontogenic tumours consisting of 20 solid ameloblastomas, five calcifying epithelial odontogenic tumours, 10 adenomatoid odontogenic tumours, 10 ameloblastic fibromas and 10 odontogenic myxomas. The distribution, intensity, pattern and localization of immunoreactive cells were determined by conventional light microscopy. chi(2) test was used for statistical analysis and P < 0.05 was considered to be significant. All 20 ameloblastomas showed intense immunopositivity with a diffuse distribution pattern. None of the other neoplasms was reactive with calretinin. Differences in the proportion of calretinin expression between groups were statistically significant at P < 0.001.
Considering that ameloblastomas, in contrast to the other studied tumours, were consistently reactive for calretinin, this protein may have a role in the pathogenesis of this aggressive neoplasm.
钙结合蛋白钙视网膜蛋白主要在某些神经元亚型中表达。据报道，它也存在于间皮瘤和其他肿瘤中。本研究旨在确定钙视网膜蛋白在特定牙源性肿瘤中的表达情况。
对55例牙源性肿瘤进行钙视网膜蛋白免疫组织化学检测，其中包括20例实性成釉细胞瘤、5例钙化上皮性牙源性肿瘤、10例腺样牙源性肿瘤、10例成釉细胞纤维瘤和10例牙源性黏液瘤。通过传统光学显微镜确定免疫反应性细胞的分布、强度、模式和定位。采用卡方检验进行统计学分析，P<0.05被认为具有统计学意义。所有20例成釉细胞瘤均显示强烈免疫阳性，呈弥漫性分布模式。其他肿瘤均未与钙视网膜蛋白发生反应。各组间钙视网膜蛋白表达比例差异具有统计学意义，P<0.001。
鉴于成釉细胞瘤与其他研究的肿瘤不同，始终对钙视网膜蛋白呈反应性，该蛋白可能在这种侵袭性肿瘤的发病机制中起作用。
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