Amant Frédéric, Han Sileny N, Gziri Mina Mhallem, Vandenbroucke Tineke, Verheecke Magali, Van Calsteren Kristel
Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Department of Oncology, KU Leuven, Leuven, Belgium.
Gynecological Oncology, Department of Obstetrics and Gynecology, University Hospitals Leuven, Department of Oncology, KU Leuven, Leuven, Belgium.
Best Pract Res Clin Obstet Gynaecol. 2015 Jul;29(5):741-53. doi: 10.1016/j.bpobgyn.2015.02.006. Epub 2015 Mar 4.
A multidisciplinary discussion is necessary to tackle a complex and infrequent medical problem such as cancer occurring during pregnancy. Pregnancy does not predispose to cancer, but cancers occurring in women of reproductive age are encountered during pregnancy. Ultrasonography and magnetic resonance imaging are the preferred staging examinations, but also a sentinel node staging procedure is possible during pregnancy. Standard cancer treatment is aimed for. Operations can safely be performed during pregnancy, but surgery of genital cancers can be challenging. The observation that chemotherapy administered during the second or third trimester of pregnancy, that is, after the period of organogenesis, has little effect on the long-term outcome of children adds to the therapeutic armamentarium during pregnancy. Cancer treatment during pregnancy adds in the continuation of the pregnancy and the prevention of prematurity.
对于处理孕期发生的癌症这类复杂且罕见的医学问题，多学科讨论是必要的。怀孕本身不会诱发癌症，但育龄期女性所患的癌症可能在孕期被发现。超声检查和磁共振成像为首选的分期检查方法，孕期也可行前哨淋巴结分期手术。治疗目标是采用标准的癌症治疗方法。孕期可以安全地进行手术，但生殖系统癌症的手术可能具有挑战性。孕期第二或第三阶段（即器官形成期之后）进行化疗对儿童长期预后影响较小，这为孕期治疗增加了手段。孕期进行癌症治疗有助于维持妊娠并预防早产。
