Sharma Hitender, Garg Munish
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, Haryana, India.
J Integr Med. 2015 Mar;13(2):80-90. doi: 10.1016/S2095-4964(15)60161-3.
Plants synthesize certain phytoconstituents for their protection, which, because they are not of primary need, are known as secondary metabolites. These secondary metabolites of plants, have often been found to have medicinal uses for human beings. One such gymnosperm having secondary metabolites of medicinal potential for humans is Taxus wallichiana (Himalayan yew). Besides being the source of taxol, this plant has been investigated for its essential oil, diterpenoids, lignans, steroids, sterols and biflavonoids. Traditionally, it is used to treat disorders of the digestive, respiratory, nervous and skeletal systems. Although pharmacologically underexplored, it has been used for antiepileptic, anti-inflammatory, anticancer, antipyretic, analgesic, immunomodulatory and antimicrobial activities. The present review compiles traditional uses, phytochemical constituents (specifically the secondary metabolites) pharmacological activities and the toxicity of T. wallichiana.
植物合成某些植物成分用于自身保护，由于这些成分并非植物的基本需求，所以被称为次生代谢产物。人们经常发现植物的这些次生代谢产物对人类具有药用价值。一种对人类具有药用潜力次生代谢产物的裸子植物是喜马拉雅红豆杉（Taxus wallichiana）。除了是紫杉醇的来源外，还对该植物的精油、二萜类化合物、木脂素、甾体、甾醇和双黄酮类化合物进行了研究。传统上，它用于治疗消化、呼吸、神经和骨骼系统疾病。尽管其药理作用尚未得到充分研究，但已被用于抗癫痫、抗炎、抗癌、退热、止痛、免疫调节和抗菌活性。本综述汇编了喜马拉雅红豆杉的传统用途、植物化学成分（特别是次生代谢产物）、药理活性和毒性。
