Yang Joon-Mo, Li Chiye, Chen Ruimin, Rao Bin, Yao Junjie, Yeh Cheng-Hung, Danielli Amos, Maslov Konstantin, Zhou Qifa, Shung K Kirk, Wang Lihong V
Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA ; These authors contributed equally to this work.
NIH Ultrasonic Transducer Resource Center, Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, University Park, Los Angeles, California 90089, USA ; These authors contributed equally to this work.
Biomed Opt Express. 2015 Feb 23;6(3):918-32. doi: 10.1364/BOE.6.000918. eCollection 2015 Mar 1.
Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all table-top embodiments, which preclude their use in internal organs. In this study, by applying the OR-PAM concept to our recently developed endoscopic technique, called photoacoustic endoscopy (PAE), we created an optical-resolution photoacoustic endomicroscopy (OR-PAEM) system, which enables internal organ imaging with a much finer resolution than conventional acoustic-resolution PAE systems. OR-PAEM has potential preclinical and clinical applications using either endogenous or exogenous contrast agents.
光学分辨率光声显微镜（OR-PAM）已成为光声断层成像的一种主要实验工具，在各种生物应用中具有独特的成像能力。然而，传统的成像系统均为台式设备，这限制了它们在内部器官成像中的应用。在本研究中，我们将OR-PAM概念应用于我们最近开发的一种内镜技术——光声内镜检查（PAE），创建了一种光学分辨率光声内镜显微镜（OR-PAEM）系统，该系统能够以比传统声学分辨率PAE系统更高的分辨率对内部器官进行成像。OR-PAEM使用内源性或外源性造影剂具有潜在的临床前和临床应用价值。
