Garten R S, Goldfarb A, Crabb B, Waller J
Geriatric Research Education and Clinical Center, George E. Whalen Veterans Affairs Medical Center, Salt Lake City, United States.
Department of Kinesiology, UNC Greensboro, Greensboro, United States.
Int J Sports Med. 2015 Jun;36(7):542-9. doi: 10.1055/s-0034-1396827. Epub 2015 Mar 25.
This study sought to examine the effects of partial vascular occlusion (PVO) on oxidative stress markers in response to resistance exercise and at rest in young resistance-trained males. 12 resistance-trained males performed 6 conditions in random counterbalanced order: rest (R), low-intensity (LIRE: 30% 1RM) and moderate-intensity (MIRE: 70% 1RM) resistance exercise with or without PVO. Blood samples were obtained before and immediately after each condition and plasma protein carbonyls (PC), glutathione ratio, oxygen radical absorbance capacity (ORAC), and xanthine oxidase (XO) were evaluated. The addition of PVO resulted in significantly greater plasma PC and glutathione ratio in the rest condition. During LIRE the addition of PVO significantly attenuated plasma PC. The MIRE condition, independent of PVO, resulted in significantly higher PC concentration and glutathione ratio compared to the rest and LIRE conditions. The addition of PVO during MIRE resulted in a significant increase in PC. Thus, this study revealed that PVO increased oxidative stress at rest and enhanced the oxidative stress response to MIRE, but when combined with LIRE oxidative stress was attenuated. These findings suggest that the utilization of PVO during LIRE may alter ROS-induced accumulation in the blood which may influence cellular signaling.
本研究旨在探讨部分血管闭塞（PVO）对年轻的抗阻训练男性在进行抗阻运动和休息时氧化应激标志物的影响。12名抗阻训练男性以随机平衡顺序进行6种情况的测试：休息（R）、低强度（LIRE：1RM的30%）和中等强度（MIRE：1RM的70%）抗阻运动，每种运动又分为有或无PVO的情况。在每种情况之前和之后立即采集血样，并评估血浆蛋白羰基（PC）、谷胱甘肽比率、氧自由基吸收能力（ORAC）和黄嘌呤氧化酶（XO）。在休息状态下，添加PVO会使血浆PC和谷胱甘肽比率显著升高。在低强度抗阻运动期间，添加PVO会显著降低血浆PC。与休息和低强度抗阻运动情况相比，中等强度抗阻运动情况（与PVO无关）会导致PC浓度和谷胱甘肽比率显著升高。在中等强度抗阻运动期间添加PVO会使PC显著增加。因此，本研究表明，PVO在休息时会增加氧化应激，并增强对中等强度抗阻运动的氧化应激反应，但与低强度抗阻运动结合时氧化应激会减弱。这些发现表明，在低强度抗阻运动期间使用PVO可能会改变活性氧诱导的血液中积累，这可能会影响细胞信号传导。
