脂质体局部用辣椒素治疗带状疱疹后神经痛：一项安全性初步研究。
Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study.
作者信息
Teixeira Manoel Jacobsen, Menezes Luciana Mendes Bahia, Silva Valquiria, Galhardoni Ricardo, Sasson José, Okada Massako, Duarte Kleber Paiva, Yeng Lin T, Andrade Daniel Ciampi de
机构信息
Departamento de Neurologia, Universidade de São Paulo, Sao Paulo, SP, Brazil.
出版信息
Arq Neuropsiquiatr. 2015 Mar;73(3):237-40. doi: 10.1590/0004-282X20140232.
UNLABELLED
Topical treatments have gained popularity for general use as an adjunct to systemic drugs in neuropathic pain, but their use produces variable clinical results and local adverse events.
OBJECTIVE
To evaluate the safety and analgesic effect of a formulation of liposomal capsaicin (LC) (0.025%) in patients with post herpetic neuralgia (PHN).
METHOD
Patients who remained symptomatic after first-and second-line treatment were randomized to receive LC for six weeks in a placebo-controlled, crossover design study. Clinical assessment was performed at baseline, in the second, fourth and sixth week of treatment.
RESULTS
Thirteen patients completed both treatment periods. Visual Analog Scale (VAS) was significantly decreased after the end of the study (p = 0.008), however the effect of treatment was not significant (p = 0.076). There was no difference on global impression of change and other pain characteristics. LC was safe and well tolerated. However, at the concentration used, its analgesic effects were marginal and not significant.
未标注
局部治疗作为治疗神经性疼痛的全身用药的辅助手段已广泛应用，但临床效果各异且会产生局部不良事件。
目的
评估脂质体辣椒素（LC）（0.025%）制剂对带状疱疹后神经痛（PHN）患者的安全性和镇痛效果。
方法
在一线和二线治疗后仍有症状的患者，在一项安慰剂对照的交叉设计研究中，随机接受LC治疗六周。在基线、治疗的第二、第四和第六周进行临床评估。
结果
13名患者完成了两个治疗期。研究结束后视觉模拟量表（VAS）显著降低（p = 0.008），但治疗效果不显著（p = 0.076）。在总体变化印象和其他疼痛特征方面没有差异。LC安全且耐受性良好。然而，在所使用的浓度下，其镇痛效果微弱且不显著。
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