Kim Myeung Ju, Kim Yi-Suk, Oh Chang Seok, Go Jai-Hyang, Lee In Sun, Park Won-Kyu, Cho Seok-Min, Kim Soon-Kwan, Shin Dong Hoon
Department of Anatomy, Dankook University College of Medicine, Cheonan, Korea.
Department of Anatomy, Ewha Womans University School of Medicine, Seoul, Korea.
PLoS One. 2015 Mar 27;10(3):e0119474. doi: 10.1371/journal.pone.0119474. eCollection 2015.
In the present study on a newly discovered 17th century Korean mummy, computed tomography (CT) revealed multiple aortic calcifications within the aortic wall that were indicative of ancient atherosclerosis. The CT-based findings were confirmed by our subsequent post-factum dissection, which exhibited possible signs of the disease including ulcerated plaques, ruptured hemorrhages, and intimal thickening where the necrotic core was covered by the fibrous cap. These findings are strong indicators that the mummy suffered from aortic atherosclerosis during her lifetime. The present study is a good example of how CT images of vascular calcifications can be a useful diagnostic tool in forming at least preliminary diagnoses of ancient atherosclerosis.
在目前对一具新发现的17世纪韩国木乃伊的研究中，计算机断层扫描（CT）显示主动脉壁内有多处主动脉钙化，这表明存在古代动脉粥样硬化。基于CT的发现通过我们随后的事后解剖得到了证实，解剖显示出该疾病的可能迹象，包括溃疡斑块、破裂出血以及坏死核心被纤维帽覆盖处的内膜增厚。这些发现有力地表明，这具木乃伊在生前患有主动脉粥样硬化。本研究是一个很好的例子，说明血管钙化的CT图像如何能够成为一种有用的诊断工具，至少在对古代动脉粥样硬化进行初步诊断方面发挥作用。
