Dong Bo, Hayashi Shigeo
Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; College of Marine Life Sciences, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, China; Institute of Evolution & Marine Biodiversity, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, China.
Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Department of Biology, Kobe University Graduate School of Science, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8051, Japan.
Curr Opin Genet Dev. 2015 Jun;32:129-34. doi: 10.1016/j.gde.2015.02.009. Epub 2015 Mar 26.
The shape of biological tubes is optimized for supporting efficient circulation of liquid and gas and to maintain organismal homeostasis. Maintaining a constant tube diameter and fitting tube length to body size are two requirements for proper tube function. The tracheal system of the Drosophila embryo is established through branching of ectodermal epithelia in the absence of environmental air, and the branching pattern and geometry of this system are genetically specified. Recent studies identified apical extracellular matrix (aECM) as a crucial regulator of tube expansion and elongation. Evidence suggests that aECM coordinates apical membrane growth and cell contractility to control tube growth at the tissue level. In the present review, we will discuss the physical mechanisms underlying this interaction.
生物管的形状经过优化，以支持液体和气体的高效循环并维持机体的稳态。保持恒定的管径以及使管的长度与身体大小相匹配是管正常功能的两个要求。果蝇胚胎的气管系统是在没有环境空气的情况下通过外胚层上皮的分支建立的，并且该系统的分支模式和几何形状是由基因决定的。最近的研究确定顶端细胞外基质（aECM）是管扩张和伸长的关键调节因子。有证据表明，aECM在组织水平上协调顶端膜生长和细胞收缩性以控制管的生长。在本综述中，我们将讨论这种相互作用背后的物理机制。
