Li Xiaoliang, Bai Yansen, Wang Suhan, Nyamathira Samuel Mwangi, Zhang Xiao, Zhang Wangzhen, Wang Tian, Deng Qifei, He Meian, Zhang Xiaomin, Wu Tangchun, Guo Huan
Department of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Occupational Disease, Institute of Industrial Health, Wuhan Iron &Steel (group) Corporation, Wuhan 430070, China.
Sci Rep. 2015 Mar 30;5:9458. doi: 10.1038/srep09458.
Epidemiological studies have shown an etiological link between body mass index (BMI) and cancer risk, but evidence supporting these observations is limited. This study aimed to investigate potential associations of BMI with chromosome damage levels and lung cancer risk. First, we recruited 1333 male workers from a coke-oven plant to examine their chromosome damage levels; and then, a cohort study of 12,052 males was used to investigate the association of BMI with lung cancer incidence. We further carried out a meta-analysis for BMI and male lung cancer risk based on cohort studies. We found that men workers with excess body weight (BMI ≥ 25 kg/m(2)) had lower levels of MN frequencies than men with normal-weight (BMI: 18.5-24.9). Our cohort study indicated that, the relative risk (RR) for men with BMI ≥ 25 to develop lung cancer was 35% lower than RR for normal-weight men. Further meta-analysis showed that, compared to normal-weight men, men with BMI ≥ 25 had decreased risk of lung cancer among both the East-Asians and others populations. These results indicate that men with excess body weight had significant decreased chromosome damage levels and lower risk of lung cancer than those with normal-weight. However, further biological researches were needed to validate these associations.
流行病学研究显示体重指数（BMI）与癌症风险之间存在病因学联系，但支持这些观察结果的证据有限。本研究旨在调查BMI与染色体损伤水平及肺癌风险之间的潜在关联。首先，我们从一家炼焦厂招募了1333名男性工人，检测他们的染色体损伤水平；然后，对12052名男性进行队列研究，以调查BMI与肺癌发病率之间的关联。我们还基于队列研究对BMI与男性肺癌风险进行了荟萃分析。我们发现，体重超重（BMI≥25kg/m²）的男性工人的微核频率低于体重正常（BMI：18.5 - 24.9）的男性。我们的队列研究表明，BMI≥25的男性患肺癌的相对风险（RR）比体重正常的男性低35%。进一步的荟萃分析显示，与体重正常的男性相比，BMI≥25的男性在东亚人群和其他人群中患肺癌的风险均降低。这些结果表明，体重超重的男性染色体损伤水平显著降低，患肺癌的风险低于体重正常的男性。然而，需要进一步的生物学研究来验证这些关联。
