Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Snyder Institute of Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Obesity (Silver Spring). 2015 Apr;23(4):769-78. doi: 10.1002/oby.21017.
Oligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet-induced obese (DIO) and diet-resistant (DR) rats.
Adult, male DIO, and DR rats were randomized to: high-fat/high-sucrose (HFS) diet or HFS diet + 10% OFS for 6 weeks. Body composition, food intake, gut microbiota, plasma gut hormones, and cannabinoid CB(1) receptor expression in the nodose ganglia were measured.
OFS reduced body weight, energy intake, and fat mass in both phenotypes (P < 0.05). Select gut microbiota differed in DIO versus DR rats (P < 0.05), the differences being eliminated by OFS. OFS did not modify plasma ghrelin or CB(1) expression in nodose ganglia, but plasma levels of GIP were reduced and PYY were elevated (P < 0.05) by OFS.
OFS was able to reduce body weight and adiposity in both prone and resistant obese phenotypes. OFS-induced changes in gut microbiota profiles in DIO and DR rats, along with changes in gut hormone levels, likely contribute to the sustained lower body weights.
低聚果糖（OFS）是一种益生元，通过改变肠道饱腹感激素和微生物群来减少能量摄入和脂肪量。OFS 的效果可能因肥胖倾向而异。本研究旨在研究 OFS 对饮食诱导肥胖（DIO）和饮食抵抗（DR）大鼠的影响。
成年雄性 DIO 和 DR 大鼠随机分为：高脂肪/高蔗糖（HFS）饮食或 HFS 饮食+10% OFS 喂养 6 周。测量身体成分、食物摄入量、肠道微生物群、血浆肠道激素和迷走神经节中大麻素 CB（1）受体表达。
OFS 降低了两种表型的体重、能量摄入和脂肪量（P<0.05）。DIO 与 DR 大鼠之间的肠道微生物群存在差异（P<0.05），OFS 消除了这些差异。OFS 并未改变迷走神经节中血浆 ghrelin 或 CB（1）表达，但 OFS 降低了血浆 GIP 水平，升高了 PYY 水平（P<0.05）。
OFS 能够降低易患和抵抗肥胖表型的体重和肥胖。OFS 诱导 DIO 和 DR 大鼠肠道微生物群谱的变化，以及肠道激素水平的变化，可能有助于持续降低体重。
